As expected, Man United will be playing a 3-4-3 formation, with Amad Diallo and Diogo Dalot featuring as the wing-backs, while Noussair Mazraoui and Jonny Evans are both included at the back.
Christian Eriksen and Casemiro are the midfield two, while Alejandro Garnacho and Bruno Fernandes will support Marcus Rashford, with the Englishman playing as the centre-forward at Portman Road.
There is big team news on the Man United bench, with Tyrell Malacia, Luke Shaw and Kobbie Mainoo all back in the squad after recovering from injury problems.
Manuel Ugarte, Joshua Zirkzee and Rasmus Hojlund are also in the away side's squad on Sunday afternoon, but there is no sign of Leny Yoro despite the Frenchman recently returning to training.
As for Ipswich, there is a start for Liam Delap, who has scored six times in 11 Premier League appearances this season, while Wes Burns is introduced into the side for the injured Ben Johnson.
Ipswich Town: Muric; Tuanzebe, O'Shea, Burgess, Davis; Morsy, Cajuste; Burns, Hutchinson, Szmodics; Delap
Subs: Walton, H Clarke, Woolfenden, Townsend, Luongo, Taylor, Chaplin, J Clarke, Al-Hamadi
Manchester United: Onana; Mazraoui, De Ligt, Evans; Amad, Casemiro, Eriksen, Dalot; Fernandes, Rashford, Garnacho
Subs: Bayindir, Malacia, Shaw, Mainoo, Mount, Ugarte, Antony, Hojlund, Zirkzee