The club captain missed PSG's Ligue 1 clash with Toulouse on Friday due to suspension, but he will be back in the XI at Allianz Arena, as Luis Enrique's side look to secure what would be a standout win.
Senny Mayulu, Lucas Hernandez, Goncalo Ramos and Presnel Kimpembe will miss the contest through injury, while a check will need to be made on Nuno Mendes, who was absent on Friday due to an ankle problem.
As well as Marquinhos, there will be returns for Vitinha, Gianluigi Donnarumma and Willian Pacho, with all three being named on the bench for the Ligue 1 contest with Toulouse.
Bradley Barcola has been in outstanding form for PSG this season, scoring 10 times in 16 appearances, and there will be another start for the Frenchman, while Marco Asensio and Ousmane Dembele should make up the front three.
Dembele has been in impressive form this season, scoring five goals and registering seven assists in 14 appearances, while Asensio, who is set to play as the centre-forward, has two goals and four assists in 13 outings.
Randal Kolo Muani has struggled to make his mark this season, and the forward is currently being linked with a loan move to Manchester United in January; he is again unlikely to be in the XI here but could have an impact off the bench.
Paris Saint-Germain possible starting lineup: Donnarumma; Hakimi, Marquinhos, Pacho, Mendes; Zaire-Emery, Vitinha, Neves; Dembele, Asensio, Barcola