The Citizens are bidding to avoid a sixth straight loss in all tournaments after Saturday's 4-0 embarrassment at the hands of Tottenham Hotspur, where Guardiola was without five players due to injury.
None of Rodri (ACL), Ruben Dias (calf), Oscar Bobb (leg) or Mateo Kovacic (unspecified) will be fit to take on Brian Priske's side either, but Jeremy Doku has a slight chance of coming back from his quadriceps problem.
Regardless, Guardiola could make more than one alteration in the final third, where Kevin De Bruyne and Jack Grealish have every right to feel confident about their chances of displacing Bernardo Silva and Phil Foden respectively.
Savinho and Erling Haaland - who needs just one more goal or assist to reach 50 direct involvements in the Champions League in record time - should be spared the axe, but the same cannot be said of an out-of-sorts Ilkay Gundogan.
After a brief stint as Man City's left-winger, Matheus Nunes could now revert to midfield duties alongside Rico Lewis, who should operate in the centre again if Kyle Walker is given the nod at right-back.
Manuel Akanji, John Stones and Ederson are also poised to hold their positions in the backline, but Josko Gvardiol endured a nightmarish evening on Saturday and could drop out for Nathan Ake.
Manchester City possible starting lineup:
Ederson; Walker, Akanji, Stones, Ake; Nunes, Lewis; Savinho, De Bruyne, Grealish; Haaland