The Spain international has not yet been officially ruled out of this match for the Catalan giants, but it is highly unlikely that the forward will be involved, with the club not prepared to take any risks when it comes to his long-term fitness.
Eric Garcia and Ferran Torres are in the latter stages of their injury recoveries and have slight chances of making the squad, though, which would certainly be welcome news for head coach Hansi Flick.
Ronald Araujo, Ansu Fati, Andreas Christensen, Marc-Andre ter Stegen and Marc Bernal are all unavailable, though, with Barcelona having a number of injury problems during the 2024-25 campaign.
Head coach Flick could make a couple of changes to the side that started against Celta Vigo on Saturday night, with Frenkie de Jong and Alejandro Balde potentially coming into the XI in place of Gavi and Gerard Martin.
Marc Casado was sent off late on against Celta before Barcelona conceded two late goals to draw 2-2, but his suspension only relates to La Liga, so the midfielder will be available here.
Robert Lewandowski and Raphinha were Barcelona's goalscorers against Celta, and the pair are again certainties in the XI for this match, while Dani Olmo is also set for another start in the final third of the field.
Barcelona possible starting lineup: Pena; Kounde, Cubarsi, I Martinez, Balde; De Jong, Casado; Olmo, Pedri, Raphinha; Lewandowski