The Cottagers have just one player in the treatment room at present, with midfielder Sasa Lukic still recovering from a shoulder injury.
Timothy Castagne recovered from a hamstring problem to feature as a substitute in Fulham's dramatic 2-1 comeback victory against Brentford on Monday and he will battle with Kenny Tete for a start at right-back.
Tete is expected to retain his place in defence, though, and is likely to be joined in the back four by former Palace man Joachim Andersen, Calvin Bassey and Antonee Robinson, while Bernd Leno continues between the sticks.
Sander Berge and Andreas Pereira seem to be Silva's first-choice centre-midfield pairing and are set to retain their starting spots ahead of Harrison Reed and Tom Cairney, while Emile Smith Rowe is expected to start in the number 10 role once again.
After coming off the substitutes' bench to score two crucial stoppage-time goals against Brentford, Harry Wilson will be hoping to force his way into the first XI. However, Silva may opt to stick with Reiss Nelson - who impressed on his first league start on Monday - and Alex Iwobi on the flanks.
Wilson and Adama Traore may therefore have to settle for a place on the bench to begin with, and the same can be said for Rodrigo Muniz who is currently playing second fiddle to first-choice centre-forward Raul Jimenez.
Fulham possible starting lineup: Leno; Tete, Andersen, Bassey, Robinson; Berge, Pereira; Iwobi, Smith Rowe, Nelson; Jimenez