Meanwhile, the visitors are looking to continue their fine start to the season, as a win here could potentially take them into the top four.
Match preview
Adana Demirspor picked up their second point of the season in a goalless draw with Kayserispor at Kadir Has Stadium last Saturday.
However, the point mattered little as the Blue Lightnings are still rooted to the bottom of the table, and are already eight points adrift of safety after playing 10 matches.
One positive for the Blue Lightnings is that they ended a six-match losing streak with the draw, but they are still on a 13-match winless run in the Super Lig dating back to the previous season.
Next in line for Adana is a first-ever top-flight meeting with Eyupspor, though both have met five times in the past across the lower divisions and once in a promotion playoff, with the Blue Lightnings winning their first two encounters, but failing to win any of the last three.
Serkan Damla was appointed as caretaker manager following the sacking of Michael Valkanis on September 23 after the poor start, but he is yet to record a win either after four matches in charge.
Meanwhile, Eyupspor will hope to pile more misery on Adana, with the visitors winning the most recent encounter between both sides, which was in the third division back in 2012.
Arda Turan's men are coming into this clash off a 2-0 win over Hatayspor at Recep Tayyip Erdogan Stadyumu last Sunday, thanks to a Mame Thiam brace.
The Istanbul-based side have taken 19 points, which has left them in fifth place after playing 11 matches, one match more than fourth-placed Besiktas who are now just one point ahead.
Eyupspor have not been able to win on the road compared to their home form, as Turan's men have only won just one of six away matches so far, and are winless in the last four, where they have lost and drawn two each.
However, the newly-promoted side are on a three-match unbeaten streak, giving them the required momentum to end their away blues when they travel to Adana.
Adana Demirspor Turkish Super Lig form:
L
L
L
L
L
D
Eyupspor Turkish Super Lig form:
L
W
L
W
D
W
Team News
Adana Demirspor have no suspended players, nor do they have any injured players, which leaves coach Damla with a wealth of options.
Yusuf Barasi will be the man to watch for Adana once again, with the striker looking to add to his four league goals, which account for 44% of his side's total league goals.
Eyupspor could remain without midfielder Recep Niyaz, who has been sidelined with a knee injury and is doubtful for this game.
Thiam has now scored three goals in his last two league matches, taking his tally to a team-high six, and he will be hoping to extend this scoring streak on Saturday.
Adana Demirspor possible starting lineup:
Karakus; Kurtulan, Guler, Gravillon, Burak; Maestro, Celik; Kol, Aydogan, Kavrazli; Barasi
Eyupspor possible starting lineup:
Ozer; Dubois, Claro, Yalcin, Erkin; Shelvey; Ampem, Kabasakal, Akbaba, Kutucu; Thiam