Eberechi Eze, Jefferson Lerma and Chris Richards are all sidelined with hamstring injuries and are joined in the treatment room by Adam Wharton (groin), Chadi Riad (knee) and Matheus Franca (groin).
Eddie Nketiah is understood to have picked up a minor hamstring issue and has emerged as a doubt, while Joel Ward could be ready to return to the matchday squad after a spell out with an unspecified problem.
Oliver Glasner is expected to name a similar side to the one that drew 2-2 with Wolverhampton Wanderers last weekend. Trevoh Chalobah and captain Marc Guehi both scored in that match and are set to continue in central defence alongside Maxence Lacroix.
Daniel Munoz and Tyrick Mitchell are expected to operate as wing-backs once again, while midfielder Cheick Doucoure could be fit to start his first league game since mid-September at the expense of either Will Hughes or Daichi Kamada.
The latter, however, could be pushed further forward if Nketiah is not deemed fit to feature and link up with Ismaila Sarr and Jean-Philippe Mateta in attack.
Crystal Palace possible starting lineup: Henderson; Chalobah, Lacroix, Guehi; Munoz, Doucoure, Hughes, Mitchell; Sarr, Kamada; Mateta
Empoli 
Udinese 
CSKA Moscow 
Rubin 
Slovan Bratislava 
AC Milan 
Sparta Praha 
Atletico Madrid 
Valencia 
Barcelona 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
RB Leipzig 
Manchester City 
Feyenoord 
Sporting CP 
Arsenal 
FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
Celtic 
Club Brugge 
Dinamo Zagreb 
Borussia Dortmund 
Liverpool 
Real Madrid 
Monaco 
Benfica 
PSV 
Shakhtar Donetsk 
Lokomotiv Moscow 
Dinamo Moscow 
Anderlecht 
FC Porto 
AZ Alkmaar 
Galatasaray 
Dynamo Kyiv 
Viktoria Plzen 
Lazio 
Ludogorets 
Qarabag 
Lyon 
FC Heidenheim 
Chelsea 
FC Midtjylland 
Eintracht Frankfurt 
Manchester Utd 
Bodo/Glimt 
Nice 
Rangers 
Real Sociedad 
Ajax 
Tottenham 
Roma