Meanwhile, the visitors will hope to continue their recent resurgence, which has seen them stay unbeaten in their last four league matches.
Match preview
Hatayspor have remained winless after 10 games into the new season, leaving them with the current longest winless run alongside bottom-placed Adana Demirspor.
Riza Calimbay's men have only three points so far, as they have lost seven times and drawn three times, which has left them second from bottom in the table.
In their most recent league outing, the Star of the South lost 2-0 against newly promoted Eyupspor in a game that saw manager Calimbay sent off by the referee.
The 4-0 victory over fourth-division side Inegol Kafkas Genclikspor in a Turkish Cup third-round fixture on October 30, is Hatayspor's only win across all competitions this season, a form that makes it increasingly likely for their five-year stay in the top flight to end.
Things are looking bleak for the Star of the South heading into their next league match, as they have failed to pick up a win against Saturday's opposition in the last five Super Lig encounters between them, losing two and drawing three, including the last two.
Meanwhile, Gaziantep will be pleased with their improvement in recent weeks, having won two of their last four matches, compared to just one win in their opening six matches.
The Hawks won two in a row for the first time in this campaign, after following the victory over Konyaspor with a 2-1 win against Goztepe last Friday.
Selcuk Inan's men went behind in the 64th minute, but Christopher Lungoyi got them back into the game with an equaliser in the 77th minute, before Deian Sorescu converted a spot kick five minutes later to take all three points.
This victory saw Gaziantep's points increase to 12 from 10 matches, and it has helped them climb to 12th place while leaving them two points above the relegation zone.
Inan's team will hope to keep up the good form in order to open a sizeable gap between them and the teams in the drop zone, and that will mean picking up a third straight win and a second on the road to end their four-match away winless streak.
Hatayspor Turkish Super Lig form:
D
L
D
L
L
L
Gaziantep Turkish Super Lig form:
D
L
D
D
W
W
Team News
Hatayspor will remain without the services of 25-year-old midfielder Chandrel Massanga, who has been sidelined with a foot injury.
The hosts are joint-lowest scorers in the league so far, and all eyes will be on Vincent Aboubakar who is expected to lead the line again, to bail them out.
Gaziantep could enter this match without Godfrey Stephen, who has been sidelined with a leg injury with no concrete recovery date.
Sorescu became the leading scorer for the Hawks in the Super Lig with three goals after finding the net last time out, making it back-to-back games with a goal, a run he will hope to extend on Saturday.
Hatayspor possible starting lineup:
Kardesler; Alici, Kilama, Calvo,Demir; Diack, Saglam; Fernandes, Pedro, Rivas; Aboubakar
Gaziantep possible starting lineup:
Dioudis; Ersoy, Kizildag, Viana; Ndiaye; Sorescu, Kozlowski, Eskihellac, Maxim; Dervisoglu, Lungoyi