Matthijs de Ligt, Lisandro Martinez and Marcus Rashford are the three players to drop out of the first XI following Sunday's 1-1 draw with Chelsea in the Premier League.
Amad Diallo replaces Rashford in the starting side, while Victor Lindelof and Jonny Evans come in for starts in the middle of the defence.
There is also good news on the bench in terms of returns, with Antony, Christian Eriksen and Mason Mount all in the squad, having recovered from their fitness problems.
Rasmus Hojlund is again given the nod as the centre-forward for the 20-time English champions, while Manuel Ugarte keeps his spot in central midfield alongside Casemiro.
As for PAOK, the Greek outfit are captained by Stefan Schwab, who has been their most influential player this season, scoring four times and registering one assist in 20 appearances in all competitions.
Taison and Abdul Rahman Baba have also scored four times this season and continue in the XI, but Shola Shoretire, who left Man United over the summer when his contract expired, is only on the bench for the Greek champions.
Manchester United: Onana; Dalot, Lindelof, Evans, Mazraoui; Casemiro, Ugarte; Amad, Fernandes, Garnacho; Hojlund
Subs: Bayindir, Heaton, De Ligt, Martinez, Mount, Rashford, Zirkzee, Eriksen, Antony, Wheatley, Amass, Fitzgerald
PAOK: Kotarski; Jonny, Kedziora, Colley, Baba; Ozdoev, Schwab; Zivkovic, Camara, Taison; Tissoudali
Subs: Monastirlis, Balomenos, Michailidis, Bakayoko, Chalov, Sastre, Thymianis, Shoretire, Brandon, Despodov