Fluminense vs. Gremio (Tuesday, 11.00pm)
Gremio can eliminate the reigning Copa Libertadores champions if they can avoid defeat on Tuesday in their second leg round of 16 tie with Fluminense at the Maracana.
Two second-half strikes powered Tricolor dos Pampas to a 2-1 triumph in the first leg of that tie in Porto Alegre last Tuesday.
We say: Fluminense 1-0 Gremio (Gremio advance on penalties)
Gremio have won eight successive competitive games against Fluminense by a single goal, and we believe that will give them a psychological edge on Tuesday.
Atletico Mineiro vs. San Lorenzo (Wednesday, 1.30am)
With a spot in the Copa Libertadores quarter-finals on the line, Atletico Mineiro host San Lorenzo in the second leg of that last-16 tie on Tuesday at Arena MRV.
Mineiro came from behind in the opening leg to claim a 1-1 draw, extending their unbeaten run away from home to two matches across all competitions.
We say: Atletico Mineiro 1-0 San Lorenzo (Atletico Mineiro advance 2-1 on aggregate)
Like the first leg, we anticipate another close encounter between these sides, but ultimately, we have more confidence in the overall quality of Mineiro than San Lorenzo.
Junior vs. Colo-Colo (Wednesday, 1.30am)
Needing a victory to keep their Copa Libertadores hopes alive, Atletico Junior host Colo-Colo on Tuesday in the second leg of that round of 16 tie at Estadio Metropolitano Roberto Melendez.
A 1-0 triumph in the opening leg last week has the Chileans in position to make the last eight of this competition for the first time since 2018.
We say: Atletico Junior 1-1 Colo-Colo (Colo-Colo advances 2-1 on aggregate)
Throughout this tournament, the Colombians have been narrowly squeaking by, and we do not see them doing enough to defeat a side as disciplined defensively as Colo-Colo.