Dynamo have seen off Partizan Belgrade and Rangers to reach the final hurdle, while Salzburg edged past Twente to progress from the third qualifying round.
Match preview
After playing out a 1-1 first-leg draw in Poland, Dynamo capitalised on their hosts going down to 10 men in Glasgow last week, as they booked a precious place in the playoffs.
When Rangers winger Jefte was sent off in the second half, the Ukrainian side went on to score twice in two minutes and secure a 3-1 aggregate success, with Oleksandr Pikhalyonok and Nazar Voloshyn netting the decisive goals.
Oleksandr Shovkovskyi's side, which finished just two points adrift of champions Shakhtar Donetsk in last term's title race, had entered Champions League qualifying in the second round with a thumping win over Partizan Belgrade
Added to two wins from two in the league, that means they are still undefeated this season, and they now aim to prolong a 12-match unbeaten streak on home turf; however, 'home' on this occasion is the Polish city of Lublin, where they will play due to the ongoing war in Ukraine.
Dynamo's most recent attempt at qualifying for Europe's top club competition ended in a 5-0 playoff defeat to Benfica two years ago, and following failure to reach the Europa Conference League last season, they are doubly determined to get back to the big time.
While their opponents were 3-1 winners over Karpaty Lviv last weekend, Salzburg saw off LASK in the Austrian Bundesliga, maintaining a flawless start to the new league season.
New boss Pep Lijnders has enjoyed an excellent start to life away from Liverpool, having returned to front-line management following a brief spell in charge of NEC Nijmegen several seasons ago.
His squad will feel they have something to prove in 2024-25, as after a decade of dominance they finally failed to win their domestic title last term, losing out to Sturm Graz on the final matchday.
Lijnders was then hired to replace Gerhard Struber, and after securing progress in the Austrian Cup and winning two league matches, Die Roten Bullen narrowly negotiated their opening Champions League qualifying tie.
After earning a 2-1 victory in the first leg at home, they played out a dramatic 3-3 draw away to Twente last week, when Maurits Kjaergaard, Dorgeles Nene and Moussa Yeo all found the net - despite conceding two late goals, they still scraped through.
Champions League regulars during the past decade, Salzburg exited at the group stage last year - finishing fourth behind Real Sociedad, Benfica and Inter Milan - and they are now intent on making another appearance as UEFA unveil a new-look format.
Dynamo Kiev Champions League form:
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Dynamo Kiev form (all competitions):
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Red Bull Salzburg Champions League form:
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Red Bull Salzburg form (all competitions):
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Team News
Dynamo are set to name a very similar XI to that which started against Rangers in last week's second leg, although Oleksandr Pikhalyonok is a strong contender to break into the lineup.
Pikhalyonok joins Oleksandr Karavaev and captain Andriy Yarmolenko - the latter of whom has scored 24 times in 100 UEFA competition appearances - on two goals in European qualifying this season.
Like Yarmolenko and Pikhalyonok, Vladyslav Vanat scored during Saturday's league win, and he will join his skipper up front in Lublin.
Centre-back Maksym Dyachuk is ruled out by an arm injury, while teenage striker Matviy Ponomarenko will be sidelined by an ankle problem.
Meanwhile, Salzburg's Karim Konate - who fired home 20 league goals last season - is still out of action with a knee injury; the Ivory Coast international joins Fernando, Takumu Kawamura and Dijon Kameri on the treatment table.
With three goals, midfielder Maurits Kjaergaard is Die Roten Bullen's leading scorer in qualifying so far, and he should start behind an attack led by either in-form Moussa Yeo or towering Serb striker Petar Ratkov.
With Konate absent, all eyes will be on another much-admired forward, Oscar Gloukh, who recently bagged a hat-trick against Blau-Weiss Linz.
Dynamo Kiev possible starting lineup:
Bushchan; Karavaev, Popov, Mykhavko, Vivcharenko; Brazhko, Shaparenko; Yarmolenko, Buyalskyi, Kabayev; Vanat
Red Bull Salzburg possible starting lineup:
Blaswich; Dedic, Baidoo, Piatkowski, Terzic; Bidstrup, Gourna-Douath, Kjaergaard; Gloukh, Yeo, Nene
We say: Dynamo Kiev 2-2 Red Bull Salzburg
Both sides have helped themselves to plenty of goals so far this season, and on effectively neutral ground, Salzburg will not be inhibited.