The Blues commenced their campaign at the weekend as Enzo Maresca's new-look side went down by a 2-0 scoreline to Premier League champions Manchester City.
While the priority will be earning a top-four finish come the end of the season, everyone associated with Chelsea are eager to go deep in this competition.
Servette have started their Swiss Super League campaign by collecting nine points from their opening five fixtures, seeing them sit in fifth position in the standings.
Here, Sports Mole rounds up Chelsea's injury and suspension news ahead of their showdown with the Maroons, who lost to Braga in Europa League qualifying.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: September 14 (vs. Bournemouth)
Having played an active part in pre-season, Reece James would have hoped to have remained fit. However, after sustaining what has been reported to be a minor hamstring injury, the right-back may not return until after the September international break.
Marc Cucurella
Status: Major doubt
Type of injury: Hamstring
Possible return date: Unknown
Marc Cucurella needed to be withdrawn during the closing stages against Man City having either suffered a hamstring issue or cramp. Either way, the decision may be taken to rest the left-back for this contest.
Ben Chilwell
Status: Major doubt
Type of injury: Illness
Possible return date: August 22 (vs. Servette)
Ben Chilwell has already been made available for transfer by Maresca but the reason for his absence on Sunday was illness. There remains a small possibility that he could feature among the replacements if Cucurella is left out of the squad.
CHELSEA'S SUSPENSION LIST
Chelsea have no suspension issues for this fixture.