The Red Devils will enter the contest off the back of a 1-0 win over Burnley in the league, while Palace drew 0-0 with Fulham, and here Sports Mole rounds up the team news for the two sides.
MANCHESTER UNITED vs. CRYSTAL PALACE
MANCHESTER UNITED
Out: Aaron Wan-Bissaka (hamstring), Luke Shaw (muscle), Kobbie Mainoo (foot), Tyrell Malacia (knee), Antony (personal), Jadon Sancho (personal), Amad Diallo (knee)
Doubtful: Lisandro Martinez (foot), Harry Maguire (muscle), Mason Mount (thigh), Sergio Reguilon (illness)
Sports Mole's predicted XI: Bayindir; Dalot, Lindelof, Evans, Reguilon; McTominay, Amrabat, Eriksen; Pellistri, Martial, Garnacho
CRYSTAL PALACE
Out: Michael Olise (thigh), Matheus Franca (back), Jefferson Lerma (hamstring), James Tomkins (calf), Naouriou Ahamada (ankle)
Doubtful: None
Sports Mole's predicted XI: Henderson; Clyne, Richards, Holding, Mitchell; Riedewald, Hughes; Rak-Sakyi, Eze, Schlupp; Mateta
For data analysis of the most likely results, scorelines and more for this match please click here.