Wigan and Rotherham have already secured promotion to the second tier and now the third and final team going up will be decided at Wembley.
Sunderland and Wycombe finished fifth and sixth respectively in the regular season but have navigated their way through the play-offs.
The Black Cats, who lost to Lincoln in the semi-finals last season, held off Sheffield Wednesday to reach Wembley.
Meanwhile, the Chairboys lost their second-leg tie to MK Dons but did enough to get through and now have the chance to clinch an immediate return to the Championship.
These two put on a pair of thrillers in the regular season with Sunderland winning 3-1 at home before a 3-3 epic at Adams Park.
Now, they'll clash in the capital and talkSPORT will have exclusive coverage of the huge League One play-off decider.
Sunderland v Wycombe: talkSPORT commentary
The League One play-off final will take place on Saturday, May 21.
talkSPORT will have exclusive coverage from Wembley with kick-off set for 3pm.
Adrian Durham will be your host and commentary will come from Sam Matterface and former Sunderland defender Micky Gray.
To tune in to talkSPORT or talkSPORT 2, click HERE for the live stream.
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Sunderland v Wycombe: Routes to the final
Sunderland
Finished regular season fifth on 84 points
Play-off semi-final - beat Sheffield Wednesday 2-1 on aggregate
Wycombe
Finished regular season sixth on 83 points
Play-off semi-final - beat MK Dons 2-1 on aggregate
Sunderland v Wycombe: Team news
Sunderland should have a fully fit squad for the play-off final but Carl Winchester is a doubt.
Forward Nathan Broadhead could start after the Welshman returned from injury for the second leg against Sheffield Wednesday.
Aiden McGeady and Leon Dajaku should also be fit.
Wycombe ace Anis Mehmeti is facing a race against time to recover from his recent injury.
Sunderland v Wycombe: What has been said?
Sunderland boss Alex Neil: "The game is a dangerous one. I think they're a tough team to beat, they've got a great habit at being in games all the time, they don't necessarily need to play well to win.
"I think they're dangerous from the first minute to the last minute, and they're not the type of team to get too caught up in the processing and how you play and all that sort of stuff.
"They want to be as effective as they possibly can and those types of teams are always dangerous.
"Sometimes they can lull you into a false sense where you are thinking you are controlling the ball and maybe creating a few chances, and then the next minute they hit you with a sucker punch.
"We know we're going to have to be focused, we know what's coming our way.
"Gareth Ainsworth and their players have done a great job getting to the final and having the opportunity to get promoted. We know how much they are going to put into it.
"We've got to match that endeavour, that effort, that aggression and everything that comes with playing Wycombe we need to match and then we need to hope we've got enough quality to win."