The Citizens have won each of their first four top-flight games thus far, although they drew a blank in front of goal in the Champions League on Wednesday night as they were held to a 0-0 draw by Inter Milan on home soil.
Arsenal, meanwhile, beat rivals Tottenham Hotspur 1-0 in the North London derby last weekend, and will do battle with Atalanta BC in the Champions League on Thursday.
Ahead of this mouthwatering top-of-the-table Premier League showdown, Sports Mole rounds up Man City's latest injury and suspension news.
Kevin De Bruyne
Status: Minor doubt
Type of injury: Groin
Possible return date: September 22 vs. Arsenal
Kevin De Bruyne has emerged as an injury doubt after he was seen clutching his groin area before being taken off at half time in the midweek draw with Inter Milan. Pep Guardiola gave a brief update on the Belgian after the match.
Nathan Ake
Status: Out
Type of injury: Muscle
Possible return date: October 20 vs. Wolves
Nathan Ake has been ruled out until after the next international break in mid-October after he was stretchered off with a muscle injury while representing the Netherlands.
Oscar Bobb
Status: Out
Type of injury: Leg fracture
Possible return date: Unknown
Oscar Bobb sustained a leg fracture in training in mid-August and he is not expected to return to first-team action until the end of the year at the earliest.
MANCHESTER CITY'S SUSPENSION LIST
Manchester City have no suspended players for this match.