The Gunners were blighted by absences but still edged out Tottenham Hotspur in Sunday's North London derby, and they can now welcome back Declan Rice, who has served a domestic suspension.
However, both Mikel Arteta and his Atalanta counterpart Gian Piero Gasperini will have key players missing in midweek. Here, Sports Mole rounds up all of the latest team news.
ATALANTA BC vs. ARSENAL
ATALANTA BC
Out: Gianluca Scamacca (ACL), Giorgio Scalvini (ACL)
Doubtful: Ibrahim Sulemana (ankle), Nicolo Zaniolo (thigh)
Sports Mole's predicted XI: Carnesecchi; Djimsiti, Hien, Kolasinac; Bellanova, Ederson, De Roon, Ruggeri; De Ketelaere, Lookman; Retegui
ARSENAL
Out: Martin Odegaard (ankle), Riccardo Calafiori (calf), Mikel Merino (shoulder), Kieran Tierney (thigh), Takehiro Tomiyasu (knee), Oleksandr Zinchenko (calf)
Doubtful: Bukayo Saka (unspecified)
Sports Mole's predicted XI: Raya; White, Saliba, Gabriel, Timber; Partey, Rice; Saka, Trossard, Sterling; Havertz
For data analysis of the most likely results, scorelines and more for this match please click here.