The Lilywhites were minutes away from seeing another shot at silverware pass them by on Wednesday night, only for late Djed Spence and Brennan Johnson goals to break Coventry City hearts in a 2-1 third-round victory.
Prior to scraping through in the cup, Ange Postecoglou's side were subjected to an agonising 1-0 North London derby defeat to Arsenal in the Premier League, leaving them with just one win from their opening four games as they languish in 13th spot.
Here, Sports Mole rounds up all of Tottenham's latest injury and suspension news ahead of the clash with the Bees, who can also look forward to an EFL Cup fourth-round showdown thanks to a 3-1 win over Leyton Orient in midweek.
Wilson Odobert
Status: Major doubt
Type of injury: Hamstring
Possible return date: September 21 (vs. Brentford)
Just 18 minutes into Wednesday's win over Coventry, Wilson Odobert was forced off the field with a suspected hamstring injury, meaning that he is highly unlikely to be seen on the pitch on Saturday.
Timo Werner
Status: Major doubt
Type of injury: Knock
Possible return date: September 21 (vs. Brentford)
Odobert was one of two Tottenham casualties on Wednesday evening, as Timo Werner - whose performance attracted severe criticism - was also forced off towards the end and has emerged as a major doubt for the weekend.
Yves Bissouma
Status: Major doubt
Type of injury: Groin
Possible return date: September 21 (vs. Brentford)
Yves Bissouma is still struggling with the groin problem that he picked up during the last international break, but Postecoglou is keeping his fingers crossed that he will be available for the clash with the Bees.
Richarlison
Status: Out
Type of injury: Unspecified
Possible return date: September 26 (vs. Qarabag)
Richarlison is still working his way back from the unspecified training injury he picked up at the end of August, and the Brazilian is now expected to return before next week's Europa League opener against Qarabag at the earliest.
TOTTENHAM'S SUSPENSION LIST
Tottenham have no players suspended for this match.