Joselu proved to be the hero for Los Blancos on Wednesday night, scoring a late brace against Bayern Munich to send the capital giants into the Champions League final.
The on-loan Espanyol forward is expected to be among those to come into the XI this weekend, with Brahim Diaz and Arda Guler also in line for attacking roles.
Luka Modric and Eduardo Camavinga both featured off the bench in the second leg of the European Cup semi-final against Bayern, and the pair are also in line for starts.
Fran Garcia and Dani Ceballos should also start, while Lucas Vazquez and Eder Militao are likely to come into the defence this weekend.
Thibaut Courtois made his first appearance of the season in the 3-0 success over Cadiz in the league last time out, and the Belgian is set for another start on Saturday.
Ancelotti could potentially play Courtois in the team's final four league games of the campaign with a view to starting the Champions League final against Borussia Dortmund on June 1.
David Alaba remains a long-term absentee due to a serious knee issue, while Aurelien Tchouameni suffered a foot injury against Bayern on Wednesday, which will rule him out of the rest of the league season, while the Frenchman is now a major doubt for the Champions League final.
Real Madrid possible starting lineup: Courtois; Vazquez, Militao, Nacho, F Garcia; Ceballos, Camavinga, Modric; Guler; Brahim, Joselu
Sparta Rotterdam 
Ajax 
Roma 
Parma 
Dundee Utd 
Celtic 
Valencia 
Alaves 
PSV 
Feyenoord 
Bordeaux 
Rennes 
ST Etienne 
Marseille 
Monaco 
Everton 
Chelsea 
Leicester 
Wolverhampton 
Manchester Utd 
Bournemouth 
Real Madrid 
Sevilla 
Cremonese 
Sampdoria 
Tottenham 
Liverpool 
VFL Wolfsburg 
Borussia Dortmund 
Las Palmas 
Espanyol 
Monza 
Juventus 
Lens 
Paris Saint Germain 
Fiorentina 
Udinese 
Benfica 
Estoril 
Inter 
Como 
Manchester City 
Fulham 
Nottingham Forest 
Motherwell 
ST Mirren 
Rangers 
Carrarese 
Arsenal 
Ipswich