Erik ten Hag's side suffered a 4-0 loss to Palace last time out, with the result keeping them in eighth spot in the Premier League table, two points behind sixth-placed Newcastle United.
The 20-time English champions will face Arsenal, Newcastle and Brighton & Hove Albion in their final three league games of the season before tackling Manchester City in the FA Cup final.
Here, Sports Mole rounds up Man United's latest injury and suspension news ahead of the clash with Arsenal, who are top of the division, one point clear of second-placed Man City.
Harry Maguire
Status: Out
Type of injury: Muscle
Possible return date: May 25 (vs. Manchester City)
Maguire will miss the end of the Premier League season due to a muscular problem, but the centre-back has a chance of being back for the FA Cup final at the end of the month.
Raphael Varane
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Varane was forced off at the interval of the recent Premier League clash with Chelsea due to another injury problem, and it remains to be seen whether he will recover before the end of the campaign.
Victor Lindelof
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Lindelof will again be absent on Sunday due to the hamstring issue which he picked up in the Premier League contest with Brentford at the end of March, and he faces a battle to be back before the season concludes.
Lisandro Martinez
Status: Major doubt
Type of injury: Calf
Possible return date: May 12 (vs. Arsenal)
Martinez picked up a calf issue during a training session last month, but the Argentina international has now returned to training and has a chance of being in the squad on Sunday.
Tyrell Malacia
Status: Out
Type of injury: Knee
Possible return date: Unknown
Malacia is bidding to recover from a knee injury which has required two separate operations, and the Dutchman will not be available for Man United until next season.
Anthony Martial
Status: Major doubt
Type of injury: Groin
Possible return date: May 12 (vs. Arsenal)
Martial, who underwent a groin operation in January, returned to team training last week, so there is a slight chance that he could be considered for selection here.
Luke Shaw
Status: Out
Type of injury: Muscle
Possible return date: May 25 (vs. Manchester City)
Shaw is currently on the sidelines with another muscular problem, but the left-back is believed to be on course to return to action before the season ends.
Willy Kambwala
Status: Out
Type of injury: Unknown
Possible return date: Unknown
Kambwala has now missed Man United's last four matches with an unspecified issue, and he will again be absent for the 20-time English champions against Arsenal.
Marcus Rashford
Status: Major doubt
Type of injury: Unknown
Possible return date: May 12 (vs. Arsenal)
Rashford has missed his side's last three matches due to a problem which he picked up against Coventry City in the semi-finals of the FA Cup, but the attacker has a chance of recovering in time to feature this weekend, as he was able to train on Thursday.
Scott McTominay
Status: Minor doubt
Type of injury: Knee
Possible return date: May 12 (vs. Arsenal)
McTominay was forced off in the latter stages of the clash against Burnley on April 27 due to a knee injury, but he was close to featuring against Palace and should therefore be available this weekend.
Bruno Fernandes
Status: Minor doubt
Type of injury: Wrist
Possible return date: May 12 (vs. Arsenal)
Fernandes missed out against Palace last time out due to a minor issue, thought to be related to his wrist, but the club captain is being backed to return to the squad on Sunday.
MANCHESTER UNITED SUSPENSION LIST
Man United have no players suspended for this match.