The Hatters are three points from safety heading into their penultimate Premier League game of the season, while the out-of-sorts Irons are planning for life without David Moyes.
Match preview
Less than a year after leading West Ham to a historic triumph in the Europa Conference League, Moyes will be vacating the London Stadium hotseat on the back of an unsightly conclusion to the 2023-24 season, both domestically and on the continent.
Including their Europa League exit at the hands of Bayer Leverkusen, the Irons are winless in six straight matches ahead of their final home game of the season, which will also be the last time that the veteran Moyes barks orders from the home dugout at the London Stadium.
The Scotsman's departure was confirmed after last week's 5-0 embarrassment at the hands of London rivals Chelsea, which saw the Hammers ship five goals on the road for the second game running, having been humiliated in similar circumstances against Crystal Palace during their end-of-season plight.
Seventh place is now the highest that Moyes's men - currently occupying ninth spot - can hope for, but they are five points behind Chelsea and Manchester United having played a game more than both sides, who need only win one of their remaining three to eliminate West Ham from European contention for good.
Before Julen Lopetegui - once of Real Madrid and Spain - takes the reins in the capital, Moyes will at least endeavour to improve the Irons' harrowing home record of just two wins from 12 games in 2024, although four of the hosts' last five contests on familiar turf have ended in a share of the points.
Another stalemate may or may not be enough for Luton to prolong their fight for survival until the 38th gameweek, but while Rob Edwards's troops can only do what they can in their final 180 minutes of football, external factors must also benefit them if a second season in the big time is to come their way.
Holding Everton to a 1-1 draw at Kenilworth Road last Friday night - where the fit-again Elijah Adebayo hit double figures for the campaign - at least snapped a three-game losing sequence in the top flight for Luton, but a handful of golden chances to nab maximum points passed them by at the end, leaving Edwards to admit he felt "sick" as Everton survived by the skin of their teeth.
Still 18th in the rankings with two games remaining, Luton will go down this weekend if Nottingham Forest - who are at home to Chelsea - better their result, or if Burnley triumph against Tottenham Hotspur and they lose to West Ham, as the Clarets and Tricky Trees square off on the final day.
The Hatters' vastly inferior goal difference to Nottingham Forest, -29 compared to -18 for the Garibaldi, is another reason for pessimism, as is their five-game losing run away from home in the Premier League, and they have not kept a clean sheet on the road all season long.
Edwards's men could therefore choose no better time to finally bolt the back door shut on enemy territory, but they could not do so in a 2-1 home defeat to West Ham back in September, and failure to exact revenge will surely lead to a premature end to their Premier League adventure.
West Ham United Premier League form:
D
W
L
L
D
L
West Ham United form (all competitions):
L
L
D
L
D
L
Luton Town Premier League form:
L
W
L
L
L
D
Team News
A trio of West Ham players are at risk of missing Moyes's London Stadium swansong this weekend, including Manchester City-owned Kalvin Phillips, whose disastrous loan spell may finish without another appearance due to a calf strain.
Defensive duo Dinos Mavropanos (knock) and Nayef Aguerd (ankle) were unavailable for the defeat to Chelsea too, although the former was making strong progress in his recovery before the trip to Stamford Bridge and might make a welcome return here.
Mavropanos would almost certainly demote Angelo Ogbonna to the bench if he is given the green light to play, while Danny Ings, Maxwel Cornet and James Ward-Prowse ought to come into Moyes's thinking after last weekend's humiliation.
Luton are not so fortunate on the injury front, though, and even though Adebayo is back with a bang following his hamstring issue, Edwards will still have to cope without at least five infirm men for the trip to London.
Tom Lockyer (heart), Issa Kabore (ankle), Marvelous Nakamba (knee), Jacob Brown (knee) and Amari'i Bell (hamstring) will not play again this season, while Edwards is also facing an unenviable decision over Dan Potts (thigh), Chiedozie Ogbene (thigh) and Mads Andersen (calf), all of whom have a chance of coming back this month.
Edwards hinted last month that he would be prepared to take risks with survival on the line, and as next weekend may be too late to save their top-flight bacon, the trio's returns could be fast-tracked for the penultimate gameweek.
West Ham United possible starting lineup:
Areola; Coufal, Zouma, Mavropanos, Emerson; Soucek, Alvarez; Kudus, Ward-Prowse, Paqueta; Bowen
Luton Town possible starting lineup:
Kaminski; Burke, Osho, Mengi; Onyedinma, Barkley, Lokonga, Doughty; Chong, Morris; Adebayo
We say: West Ham United 2-2 Luton Town
West Ham have developed an affinity for home stalemates as the campaign draws to a close, and this weekend's encounter against a desperate Luton side who almost always pose a threat in the final third may be no different.