The Saints will spend Christmas Day at the bottom of the standings no matter what transpires this weekend, while Marco Silva's men are bidding to boost their European prospects, and here Sports Mole rounds up the team news for both clubs.
FULHAM vs. SOUTHAMPTON
FULHAM
Out: Andreas Pereira (suspended), Kenny Tete (knee), Harrison Reed (knee), Reiss Nelson (thigh)
Doubtful: Joachim Andersen (calf)
Sports Mole's predicted XI: Leno; Castagne, Andersen, Bassey, Robinson; Lukic, Berge; Iwobi, Smith Rowe, Wilson; Jimenez
SOUTHAMPTON
Out: Jack Stephens (suspended), Will Smallbone (thigh), Gavin Bazunu (Achilles), Ross Stewart (calf)
Doubtful: Aaron Ramsdale (finger), Kyle Walker-Peters (knock)
Sports Mole's predicted XI: Ramsdale; Harwood-Bellis, Bednarek, Wood; Sugawara, Downes, Fernandes, Walker-Peters; Dibling, Armstrong; Archer
For data analysis of the most likely results, scorelines and more for this match please click here. Written by
Ben Knapton
Sparta Rotterdam 
Ajax 
Roma 
Parma 
Dundee Utd 
Celtic 
Valencia 
Alaves 
PSV 
Feyenoord 
Bordeaux 
Rennes 
ST Etienne 
Marseille 
Monaco 
Everton 
Chelsea 
Leicester 
Wolverhampton 
Manchester Utd 
Bournemouth 
Real Madrid 
Sevilla 
Cremonese 
Sampdoria 
Tottenham 
Liverpool 
VFL Wolfsburg 
Borussia Dortmund 
Las Palmas 
Espanyol 
Monza 
Juventus 
Lens 
Paris Saint Germain 
Fiorentina 
Udinese 
Benfica 
Estoril 
Inter 
Como 
Manchester City 
Fulham 
Nottingham Forest 
Motherwell 
ST Mirren 
Rangers 
Carrarese 
Arsenal 
Ipswich