The Danish midfielder has not played a professional match since Euro 2020 last summer where he went into cardiac arrest during Denmark's clash against Finland.
Fans were fearing the worst as he received treatment in front of the watching world, so his return to football is going to be a joyful moment for all involved.
Eriksen, who left Inter Milan by mutual consent in December, completed a move to Brentford in the January transfer window.
Frank told journalists: "Christian Eriksen will be in the squad and he will get on the pitch tomorrow. It will be amazing. It's a big day for all of us but especially Christian and his family when he walks onto that pitch.
"For everyone involved in football who saw what happened, it's another one of those reminders that we are privileged to do what we do and be alive and we need to appreciate every day and every moment, which is very difficult in everyday life, but a good reminder for us all to be aware.
"The key thing is that everything has been checked. All is good and there's zero chance that something should happen and he and his family are aligned that he should play football. I think that's very important. I can't wait."
While Eriksen is set to receive a wonderful reception from all corners of the ground when he appears at the Brentford Community Stadium, some will no doubt be anxious about his return to elite level sport given what happened last summer.
However, speaking exclusively to talkSPORT earlier in February, the playmaker revealed that he would never have agreed to come back if he was worried about the repercussions.
"If there was any anxiety I wouldn't go back," he said.
"If I wasn't fully committed and trusting the doctors and my heart and my ICD then I wouldn't go back, so I feel 100 per cent secure to go back."
Speaking of his decision to join Brentford, he added: "Thomas Frank was very important.
"He obviously wanted me to come here if it was possible, and at the time it was the perfect mix for me as a football player and also the family.
"Before I was not planning on coming back to England, that was not on my mind.
"But after the incident it became clearer and clearer the longer it went on that I couldn't play in Italy because of the ICD.
"And then of course my mindset changed that if it can't be Italy the best option would be England and the Premier League, a London club for the family was the perfect mix."