The 17-year-old has missed Barcelona's last three matches with an ankle problem, but the attacker, who has six goals and eight assists in 16 appearances this season, is in line to make his return against Las Palmas.
Ferran Torres is also back in training, with the forward recovering from a hamstring problem, but Ronald Araujo will once again be unavailable despite making excellent progress in his recovery from a hamstring issue of his own.
Marc Casado will sit this match out due to a suspension, with the midfielder being sent off in last weekend's 2-2 draw with Celta Vigo, which should open the door for Frenkie de Jong to start in the middle.
Ansu Fati, Andreas Christensen, Marc-Andre ter Stegen and Marc Bernal are also injured for Barcelona, with the Catalan outfit having a number of fitness problems during the 2024-25 campaign.
Alejandro Balde was named on the bench against Brest in the Champions League on Tuesday night, but the Spain international is expected to be back in the side at left-back on Saturday afternoon.
Dani Olmo, Raphinha and Robert Lewandowski are also set to feature in the final third of the field, but Gavi might have to accept a spot on the bench once again.
Barcelona possible starting lineup: Pena; Kounde, Cubarsi, I Martinez, Balde; De Jong, Pedri; Yamal, Olmo, Raphinha; Lewandowski