The Toffees goalkeeper dropped a Juan Mata free-kick and subsequently kicked England teammate and Red Devils captain Harry Maguire in the box.
Maguire's shot failed to hit the target, but he felt the full force of Pickford's left boot, along with another kick from Michael Keane at the same time.
Despite the clear contact, referee Paul Tierney awarded a goal kick to Everton and not a United penalty.
The incident was reviewed by VAR official Michael Oliver, who was the referee when Pickford injured Virgil van Dijk during last month's 2-2 draw with Liverpool, but deemed legal.
The reckless tackle, which saw him go unpunished, resulted in anterior cruciate ligament damage for Van Dijk.
And Pickford appeared to get away with one again against Manchester United.
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talkSPORT commentator called Pickford's actions 'wild' and 'uncontrolled'.
He said: "It was wild and uncontrolled from Pickford. He's got away with that.
"It was his instincts taking over again, and his instincts weren't the best. It was another untidy moment in the life of Jordan Pickford."
Jordan Pickford was lucky not to concede a penalty during Everton's clash with Manchester United on Saturday.