While some titles and relegation battles look set to go down to the wire in thrilling fashion, others could be wrapped up with weeks of the 2023-24 campaign still to spare.
This weekend, Bayer Leverkusen could create history by winning their first ever Bundesliga crown - ending Bayern Munich's unprecedented era of dominance in the process.
Promotions could also be secured in both League One and League Two in England, while an inevitable relegation from the Turkish Super Lig could finally be confirmed.
Here, Sports Mole rounds up all of the permutations from around Europe's top leagues for this weekend, and outlines exactly what each club needs to do to fulfill those possibilities.
What could be decided across Europe this weekend?
Bundesliga
Bayer Leverkusen will be crowned champions this weekend if both Bayern Munich and Stuttgart lose on Saturday. If one or both of Bayern and Stuttgart avoid defeat, then Leverkusen will win the title if they match or better the best result from those two matches when they face Werder Bremen on Sunday.
League One
Portsmouth will be promoted and crowned champions if they beat Bolton Wanderers on Saturday. They will also be promoted if they draw and Derby County drop points against Leyton Orient. Even defeat could be enough if both Derby and Peterborough United also lose.
League Two
Stockport County will be promoted if they avoid defeat to Morecambe. Defeat could even be enough if MK Dons fail to win. Stockport will be crowned champions if they win and both Wrexham and Mansfield lose their fixtures.
Wrexham could be promoted if they beat Forest Green Rovers and both MK Dons and Barrow drop points.
Turkish Super Lig
Istanbulspor will be relegated if they fail to beat Hatayspor on Sunday.
What has already been decided?
Championship
Rotherham United were relegated from the Championship on April 5 following a 1-0 defeat to Plymouth Argyle.
League One
Carlisle United were relegated from League One on April 6 following a 2-0 defeat to Northampton Town.
National League
Chesterfield were promoted from the National League on March 23 courtesy of a 3-0 win over Boreham Wood.
Obolon-Brovar Kyiv 
Shakhtar Donetsk 
Sampdoria 
Frosinone 
Bayern Munich 
FC ST. Pauli 
Holstein Kiel 
Werder Bremen 
VFL Wolfsburg 
FC Heidenheim 
Celtic 
Heart Of Midlothian 
Espanyol 
Atletico Madrid 
Reims 
Marseille 
Rukh Lviv 
Dynamo Kyiv 
CSKA Moscow 
FK Makhachkala 
Juventus 
Genoa 
Eintracht Frankfurt 
VFB Stuttgart 
Dundee 
Rangers 
ST Etienne 
Paris Saint Germain 
Metz 
Bordeaux 
Lecce 
Roma 
Real Madrid 
Leganes 
NEC Nijmegen 
AZ Alkmaar 
Monaco 
Nice 
PSV 
Ajax 
Fiorentina 
Atalanta 
Akhmat Grozny 
Spartak Moscow 
Barcelona 
Girona 
Feyenoord 
Go Ahead Eagles 
Auxerre 
Montpellier 
Bournemouth 
Manchester City 
Borussia Dortmund 
FSV Mainz 05 
Inter 
Udinese 
Valencia 
Mallorca 
Estoril 
FC Porto