The Gunners will enter the contest off the back of a 2-2 draw with Bayern Munich in the first leg of their Champions League quarter-final in North London.
Arsenal beat Brighton & Hove Albion 3-0 in the league last weekend, and Mikel Arteta's side currently sit top of the table, ahead of second-placed Liverpool on goal difference.
Here, Sports Mole rounds up the capital club's latest injury and suspension news ahead of their clash with Villa, who are fifth in the division, level on points with fourth-placed Tottenham Hotspur.
Jurrien Timber
Status: Out
Type of injury: Knee
Possible return date: Unknown
Timber is currently the only Arsenal player unavailable for selection, with the Netherlands international still working his way back from the serious knee injury that he sustained last August. However, he has returned to training and is expected to be back in action before the end of the campaign.
ARSENAL'S SUSPENSION LIST
Arsenal have no players suspended for this match.
Obolon-Brovar Kyiv 
Shakhtar Donetsk 
Sampdoria 
Frosinone 
Bayern Munich 
FC ST. Pauli 
Holstein Kiel 
Werder Bremen 
VFL Wolfsburg 
FC Heidenheim 
Celtic 
Heart Of Midlothian 
Espanyol 
Atletico Madrid 
Reims 
Marseille 
Rukh Lviv 
Dynamo Kyiv 
CSKA Moscow 
FK Makhachkala 
Juventus 
Genoa 
Eintracht Frankfurt 
VFB Stuttgart 
Dundee 
Rangers 
ST Etienne 
Paris Saint Germain 
Metz 
Bordeaux 
Lecce 
Roma 
Real Madrid 
Leganes 
NEC Nijmegen 
AZ Alkmaar 
Monaco 
Nice 
PSV 
Ajax 
Fiorentina 
Atalanta 
Akhmat Grozny 
Spartak Moscow 
Barcelona 
Girona 
Feyenoord 
Go Ahead Eagles 
Auxerre 
Montpellier 
Bournemouth 
Manchester City 
Borussia Dortmund 
FSV Mainz 05 
Inter 
Udinese 
Valencia 
Mallorca 
Estoril 
FC Porto