Wilson has been left out of the matchday squad due to a hamstring injury, and tonight's game has also come too soon for Joelinton who is nursing a thigh strain; Harvey Barnes (ankle), Joe Willock (Achilles) and Sven Botman (knee) also miss out.
Eddie Howe has made just the one change to the lineup that began the 2-0 Premier League win over Burnley last weekend, with Sandro Tonali starting in centre-midfield alongside Sean Longstaff and Bruno Guimaraes at the expense of Elliot Anderson.
Jamaal Lascelles will captain Newcastle in the back four alongside Kieran Trippier, Fabian Schar and Dan Burn, while Alexander Isak will lead the line in Wilson's absence, joining Miguel Almiron and Anthony Gordon in attack.
As for PSG, Luis Enrique has made four changes to the side that was frustrated in a 0-0 draw with Clermont in Ligue 1 last weekend, with Lucas Hernandez, Manuel Urgate, Warren Zaire-Emery and Goncalo Ramos all coming in for Danilo Pereira, Bradley Barcola, Fabian Ruiz and Vitinha.
The Ligue 1 champions are set to revert from a 3-4-3 formation to an attacking 4-2-4 setup, with Hernandez starting at left-back in a back four including Milan Skriniar, Marquinhos and Achraf Hakimi.
Seventeen-year-old Zaire-Emery will partner Urgate in centre-midfield, while star attacker Mbappe, who has already scored eight goals in just seven games across all competitions this season, will join Ousmane Dembele, Randal Kolo Muani and Ramos in attack.
Newcastle United: Pope; Trippier, Lascelles, Schar, Burn; Longstaff, Guimaraes, Tonali; Almiron, Isak, Gordon
Subs: Dubravka, Karius, Dummett, Targett, Hall, Livramento, Murphy, Anderson, Miley
Paris Saint-Germain: Donnarumma; Hakimi, Marquinhos, Skriniar, Hernandez; Ugarte, Zaire-Emery; Dembele, Kolo Muani, Mbappe; Ramos
Subs: Navas, Tenas, Ruiz, Pereira, Vitinha, Mukiele, Soler, Barcola
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