The summer arrival's position has come under scrutiny since he moved ahead of Aaron Ramsdale in the pecking order, and he was the subject of further criticism after being lobbed against Chelsea during Saturday's 2-2 draw between the two sides.
Ramsdale was unavailable for that match due to the birth of his child, but he is back for Tuesday's game in Spain, albeit having to make do with a place on the bench.
Raya retains the gloves in a starting XI that shows just one change from that trip to Stamford Bridge last weekend.
Takehiro Tomiyasu comes into the side for the Gunners following his cameo from the bench on Saturday, starting at left-back in place of Oleksandr Zinchenko.
Thomas Partey is a notable absentee from the bench for Arteta, though, with the club confirming that he has been ruled out due to a muscle injury.
Sevilla have named an unchanged side from the one which drew 1-1 with Real Madrid last time out, a match that was manager Diego Alonso's first at the helm.
Ivan Rakitic, Sergio Ramos and Jesus Navas are among their starters, with the latter having also featured in the only two previous competitive meetings between the two sides in 2007-08.
The Spanish outfit also have former Tottenham Hotspur midfielder Erik Lamela amongst their substitutes.
Sevilla: Nyland; Navas, Gudelj, Ramos, Acuna; Sow, Soumare, Rakitic; Lukebakio, En-Nesyri, Ocampos
Subs: Dmitrovic, Gattoni, Pedrosa, Suso, Jordan, Rafa Mir, Nianzou, Lamela, Oliver, Juanlu
Arsenal: Raya; White, Saliba, Gabriel, Tomiyasu; Odegaard, Rice, Jorginho; Saka, Jesus, Martinelli
Subs: Ramsdale, Hein, Zinchenko, Cedric, Kiwior, Elneny, Havertz, Vieira, Smith Rowe, Trossard, Nelson, Nketiah