Ange Postecoglou's side suffered a demoralising 3-2 defeat at Brighton & Hove Albion before the international break, letting slip a two-goal half-time advantage to succumb to the Seagulls.
Spurs now find themselves down in ninth position in the Premier League standings ahead of another hectic run of fixtures in three different competitions.
Here, Sports Mole rounds up all of Spurs' latest injury and suspension news ahead of the clash with one of their city rivals at the Tottenham Hotspur Stadium.
Son Heung-min
Status: Major doubt
Type of injury: Thigh
Possible return date: October 19 (vs. West Ham)
Son Heung-min has missed the last three Spurs fixtures in all competitions, as well as South Korea's matches during the international break. However, the club captain suggested over the weekend that he would be returning to training this week, albeit it remaining unclear at what intensity.
Wilson Odobert
Status: Major doubt
Type of injury: Hamstring
Possible return date: October 19 (vs. West Ham)
During Tottenham's EFL Cup win over Coventry City in September, summer signing Wilson Odobert damaged his hamstring. He has since missed the last five games but, like with Son, he may be in a position to return to training this week.
Richarlison
Status: Major doubt
Type of injury: Calf
Possible return date: October 19 (vs. West Ham)
Richarlison is also pushing for a return to the squad having made progress in his recovery from a calf injury. The Brazil international has already gone through some work during the international break, the hope being that he can step up that effort ahead of the Hammers game.
Lucas Bergvall
Status: Major doubt
Type of injury: Unknown
Possible return date: October 19 (vs. West Ham)
Lucas Bergvall has emerged as a doubt courtesy of what has been described as "a minor injury" while on international duty with Sweden.
TOTTENHAM'S SUSPENSION LIST
Spurs have no players who are suspended for this contest.