Carlo Ancelotti's side were held to a 1-1 draw by Girona in the league last weekend, but it was still enough for them to return to the top of the table ahead of Barcelona.
Real Madrid will enter this match off the back of a victory, though, having thumped Celtic 5-1 in the Champions League on Wednesday to secure first position in their section.
Here, Sports Mole rounds up Real Madrid's latest injury and suspension news ahead of their contest with Rayo Vallecano, who currently sit in ninth position in the table.
Aurelien Tchouameni
Status: Major doubt
Type of injury: Muscle
Possible return date: November 7 (vs. Rayo Vallecano)
Aurelien Tchouameni has now missed Real Madrid's last two matches with a muscular problem, and the midfielder faces a battle to be available for the clash with Rayo.
Eden Hazard
Status: Major doubt
Type of injury: Muscle
Possible return date: November 7 (vs. Rayo Vallecano)
Eden Hazard was not involved against Celtic on Wednesday due to a muscular problem, and the Belgium international remains a major doubt for Monday's match.
REAL MADRID'S SUSPENSION LIST
Toni Kroos
Status: Out
Possible return date: November 10 (vs. Cadiz)
Real Madrid will be missing Toni Kroos through suspension on Monday, with the experienced midfielder shown a red card in the latter stages of the draw with Girona last time out.