The Gunners sit at the top of the table and have won their last three games away at the Blues.
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Mikel Arteta now faces a reunion with former striker Pierre-Emerick Aubameyang who left the club with a poor relationship with the Spanish boss.
Aubameyang will be out to hand his former club only their second loss of the season and put an end to his side's three-game winless run.
Blues manager Graham Potter was beaten on his return to Brighton last time out and will be eager to return to winning ways this weekend.
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Chelsea vs Arsenal: talkSPORT coverage
This Premier League clash will be played on Sunday, November 6.
Kick-off at Stamford Bridge is scheduled for 12pm.
talkSPORT will provide EXCLUSIVE live coverage of the game presented by Faye Carruthers.
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Commentary comes from Clive Tyldesley and former Chelsea defender Scott Minto.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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Chelsea vs Arsenal: Team news
The hosts will have Ben Chilwell out after he picked up a hamstring injury in midweek which is likely to see him miss the World Cup.
Reece James, Wesley Fofana and N'Golo Kante will be also be missing with long-term injuries. Edouard Mendy will start in goal with the in-form Kepa sidelined.
Oleksandr Zinchenko made his return to the matchday squad in Europe and could feature while Emile Smith Rowe will be out.
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Bukayo Saka is fit after recovering from his knock against Nottingham Forest after initial worries about the severity of the issue.
Chelsea vs Arsenal: What has been said?
Arsenal boss Arteta is aware of the threat his former striker Aubameyang will bring on Sunday.
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He said: "[He's] very dangerous. If Auba has something, it's the ability to put the ball in the back of the net.
"He's going to be doing that until the day that he decides he's had enough of football.
"We will have to look first of all at what Chelsea do and try to put a plan together to avoid that."
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Chelsea vs Arsenal: Match facts
In his first Premier League game of the season last time out, Arsenal's Reiss Nelson scored twice and assisted another in a 63-minute substitute appearance. He'd only been involved in one goal in his previous 23 such games, with that being a goal against Liverpool in his last start in the competition in July 2020.
Chelsea striker Pierre-Emerick Aubameyang scored 68 goals in 128 Premier League games for Arsenal between 2018 and 2021, including one against the Blues in December 2019 - he could become just the second player to score for both sides in this fixture in the Premier League (excluding own goals), after Cesc Fàbregas.
Arsenal forward Gabriel Jesus has had more touches in the opposition box than any other player in the Premier League this season (124). He's averaging 10.7 such touches per 90 minutes, with the leading player for the Gunners in this regard last term averaging just 7.7 (Nicolas Pépé, minimum 500 minutes played).
Chelsea manager Graham Potter has won three of his six Premier League games against Arsenal (D1 L2) - no side has he beaten more often in the competition than the Gunners.
Arsenal have scored more goals in the opening 30 minutes of Premier League games this season than any other side (11), while they're the only side yet to concede in this timeframe. The Gunners are also one of three sides yet to concede in the final 15 minutes of games (along with Brighton and Southampton), netting five goals themselves.
Chelsea lost 4-1 against Brighton last time out, last losing consecutive league games in December 2020 under Frank Lampard. However, at home the Blues are unbeaten in nine league games (W5 D4) since a 4-2 loss to Arsenal in April.
Arsenal have won their last four Premier League London derbies, last winning more consecutively between April and October 2013 (5). They've won both such away games without conceding so far this season - they've never won three in a row while keeping a clean sheet each time before.
Each of Arsenal's last six Premier League goals against Chelsea have been scored by English players, with Bukayo Saka, Emile Smith Rowe and Eddie Nketiah each netting twice. Just six of the Gunners' previous 54 league strikes (excl. own goals) against the Blues between 1999 and 2020 were scored by Englishmen.
Arsenal have won their last two Premier League away games against Chelsea, as many as in their previous 16 visits. They've not won three in a row at Stamford Bridge since April 1974.
Chelsea have lost three of their last four Premier League games against Arsenal (W1), more than they had in their previous 17 against the Gunners (W9 D6 L2).