Ruben Selles's basement-dwellers were put to the sword 2-0 by Brentford in midweek, while the Lilywhites most recently cruised past Nottingham Forest 3-1 last weekend.
Match preview
There was no shortage of attacking endeavour from Southampton during a rainy visit of Brentford on Wednesday night, but the Bees' cutting edge set them apart from their South Coast counterparts, whose survival task became all the more arduous with defeat to Thomas Frank's crop.
A well-worked set-piece routine ended with Ivan Toney prodding home the game's opening goal on the 32-minute mark, and the striker soon turned provider for Yoane Wissa, who raced through to slot home merely seconds after Southampton had lost a duel from a goal-kick.
From arguably being unfortunate not to have beaten Manchester United at Old Trafford to remaining bottom of the table with a humbling loss to Brentford, Southampton still only have a two-point gap separating them from the safety of 17th spot, but their relegation rivals now crucially boast a game in hand.
Southampton can only rely on so many James Ward-Prowse set-piece situations to bail them out of trouble, but the Saints can now boast a paltry three goals from their last eight Premier League contests, while six of their last seven Premier League home games have now ended in defeat.
Silver linings are few and far between at St Mary's right now, but conceding just three goals in their last five Premier League matches - keeping clean sheets against Chelsea and Man United - can be viewed in a positive light, although that may not count for much against a rejuvenated Spurs outfit.
Southampton are a far cry from the team they were under Mauricio Pochettino, who has been strongly linked with a sensational return to Tottenham as Antonio Conte runs down the final few months on his contract, but the Italian's fiery passion on the touchline was there for all to see during the visit of Forest.
Richarlison may have seen a strike chalked off within three minutes as his wait for a first Premier League goal for Tottenham goes on, but Harry Kane's 19th and 20th goals of the season preceded a final Son Heung-min effort before Joe Worrall gave the Forest faithful something to cheer in the dying embers.
Conte's side were also indebted to a last-gasp Fraser Forster penalty save from Andre Ayew for preventing a true squeaky bum time finish, but by bringing a miserable week to a pleasant end, their fourth-placed standing in the Premier League table remains safe for the time being.
The Lilywhites are out of sight of Liverpool, but Newcastle United have two games in hand to make up a four-point deficit, so Spurs' hopes of Champions League qualification - which Conte claimed would be akin to winning a trophy - are still out of their own hands.
While the Tottenham Hotspur Stadium fortress still has its walls intact, Spurs travel to St Mary's having suffered an abysmal four away defeats in succession across all tournaments, failing to score in each of their last three against AC Milan, Sheffield United and Wolverhampton Wanderers.
It has been just over 40 years since Spurs last lost four successive away games without finding the back of the net, but they strolled to a 4-1 success over Southampton during the opening weekend of the 2022-23 season, having been held to a 1-1 draw at St Mary's last season.
Southampton Premier League form:
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Southampton form (all competitions):
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Tottenham Hotspur Premier League form:
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Tottenham Hotspur form (all competitions):
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Team News
Ex-Tottenham right-back Kyle Walker-Peters would have been expected to strut his stuff against his former employers this week, but the 25-year-old came off with a hamstring concern in the loss to Brentford and will need assessing in the coming days.
Fellow full-back Valentino Livramento remains out of contention alongside Juan Larios, while Arsenal loanee Ainsley Maitland-Niles is still nursing a knock and will also need a once-over, potentially limiting Selles's right-back options further.
James Bree can feel confident of coming into the first XI if Walker-Peters misses out, while neither Mohamed Elyounoussi nor Kamaldeen Sulemana cut the mustard in midweek, so Theo Walcott - hardly a favourite of Tottenham fans - ought to be in contention for a recall.
As for Spurs, the long-term quartet of Hugo Lloris, Yves Bissouma, Rodrigo Bentancur and Ryan Sessegnon all remain absent, while there is also a question mark hanging over the head of Emerson Royal, who has been battling a knock.
The Brazilian should have a strong chance of coming back here, but Pedro Porro has seemingly cemented his place in the XI since Emerson's purple patch came to an end, while Richarlison should certainly hold the fort up front again, having improved his self-confessed "s***" fortunes with a stellar showing against Forest.
The stage is seemingly set for Richarlison to finally break his Premier League duck for Spurs, as the Brazilian has five goals against the Saints in the Premier League - a personal high - while Son Heung-min is one away from bringing up a century of English top-flight goals.
Southampton possible starting lineup:
Bazunu; Bree, Bednarek, Bella-Kotchap, Perraud; Ward-Prowse, Lavia; Walcott, Alcaraz, Sulemana; Onuachu
Tottenham Hotspur possible starting lineup:
Forster; Romero, Dier, Lenglet; Porro, Hojbjerg, Skipp, Davies; Richarlison, Kane, Son
We say: Southampton 0-1 Tottenham Hotspur
A continued lack of ruthlessness and midweek fatigue will no doubt work against Southampton versus their more esteemed counterparts, who are primed to snap their dampening run of away defeats on the South Coast.