The Red Devils go into the Europa League clash with Real Betis without a number of key players as they look to finish the job after their 4-1 first leg victory.
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Alejandro Garnacho is expected to be out for a number of weeks, while Antony and Anthony Martial have not travelled to Spain for the second leg test.
Add into that Christian Eriksen and Donny van de Beek being long-term absentees and Casemiro's four-match domestic ban, Ten Hag is starting to feel the pinch.
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Ten Hag explained: "Man City home [2-1 victory in January], it was the only time this season [that United had a fully fit squad], in other times, every time, every game is a player suspended, injured, illness.
"So we have to deal with it well, of course, you hope.
"I see Arsenal, they almost have all the time a squad that is totally available."
His claims about Arsenal's injury record might not go down particularly well in north London, though.
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Emile Smith Rowe was a key player for the Gunners last year but has missed large chunks of this term through persistent injuries.
Arteta has also been without his star striker, Gabriel Jesus, since the World Cup, with the Brazilian star only just coming back into contention.
With Eddie Nketiah also now sidelined with a fresh injury, Arsenal will have work to do to maintain their current run of form to the end of the season as they look to claim their first title in 19 years.
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