The hosts, meanwhile, as seeking to avoid a fifth consecutive game without a victory in all competitions.
Match preview
After securing an impressive seventh-placed finish and reaching the Copa del Rey final last season, Osasuna have since endured a difficult start to the new campaign, winning just two of their opening eight games across all competitions.
Los Rojillos began the month of September with back-to-back La Liga losses to Barcelona and Getafe before playing out a goalless draw with Sevilla last weekend, firing just two of their 16 shots on target in a frustrating contest on home soil.
Jagoba Arrasate's side have subsequently slipped to 11th in the La Liga table, and at this early stage they find themselves sitting three points above the relegation zone as well as three points behind Thursday's opponents Atletico Madrid in fifth place.
Osasuna's early-season form at Estadio El Sadar will be a cause for concern for Arrasate as they have failed to win any of their first four home matches in all tournaments, losing three times and scoring just two goals in the process, despite ending last season with five home wins in their last six games.
Hopes of securing their maiden home win of the new campaign on Thursday could prove challenging, though, as Los Rojillos have not beaten Atletico Madrid on their own turf since a 3-0 win in February 2014.
Atletico Madrid travel to Estadio El Sadar in buoyant mood after claiming a 3-1 home victory over Real Madrid on Sunday evening - ending a three-game winless streak against their city rivals.
Two goals inside the opening 18 minutes from Alvaro Morata and Antoine Griezmann put Atletico in control, before a sweet strike from Toni Kroos 10 minutes before the break restored hope for Los Blancos.
However, Los Cochoneros did not take long to regain their two-goal cushion as Morata found the net just 30 seconds into the second half, and Atletico eventually held on for an impressive derby triumph to climb into the top five of La Liga.
Diego Simeone is now tasked with finding consistency for his Atletico side, who had previously beaten Rayo Vallecano 7-0, lost 3-0 at Valencia and drawn 1-1 with Lazio in their Champions League group-stage opener.
Los Cochoneros will be confident of claiming back-to-back La Liga wins for the first time this season on Thursday as they have won each of their last 10 meetings with Osasuna, winning their last five away encounters by an aggregate score of 15-1.
Osasuna La Liga form:
W
L
W
L
L
D
Osasuna form (all competitions):
L
W
D
L
L
D
Atletico Madrid La Liga form:
D
W
D
W
L
W
Atletico Madrid form (all competitions):
D
W
W
L
D
W
Advert - content below:
Team News
Osasuna are set to be without injured duo Jon Moncayola (foot) and Darko Brasanac (ACL), while Unai Garcia (fitness) is doubtful and will be assessed ahead of kickoff.
Arrasate is expected to stick with a back four of Ruben Pena, Alejandro Catena, David Garcia and Juan Cruz, with Sergio Herrera set to retain the goalkeeper gloves at the expense of Aitor Fernandez.
Raul Garcia and Kike Barja will both be looking to force their way into the first XI, but attacking trio Ezequiel Avila, Ante Budimir and Johan Mojica could all keep their places in the final third.
As for Atletico Madrid, they are still having to cope without Thomas Lemar (Achilles), Pablo Barrios (foot), Caglar Soyuncu (hip), Rodrigo De Paul (muscle), Reinildo and Vitolo (both knee) due to injury.
Captain Koke recovered from a hamstring injury to start and play the first 45 minutes against Real Madrid, and another start in centre-midfield could be on the cards for the 31-year-old, although he faces competition from Axel Witsel to line up alongside Marcos Llorente and Saul.
Atletico were also boosted by the return of Memphis Depay last weekend, with the Dutchman recovering from a muscle problem to feature as a second-half substitute; a start on Thursday seems unlikely, though, considering the impressive performances of both Morata and Griezmann in attack last time out.
Osasuna possible starting lineup:
Herrera; Pena, Catena, D. Garcia, Cruz; Munoz, Torro, Oroz; Avila, Budimir, Mojica
Atletico Madrid possible starting lineup:
Oblak; Savic, Gimenez, Hermoso; Molina, Saul, Llorente, Koke, Lino; Griezmann, Morata
We say: Osasuna 0-2 Atletico Madrid
Atletico Madrid will be considered firm favourites to win on Thursday and have every reason to feel confident of securing maximum points against an Osasuna side who are yet to find their groove in the early stages of this season.