The hosts hold a three-point advantage over the winless Europa League holders and simply need to avoid defeat to deny Los Palanganas another shot at redemption in the continent's secondary tournament.
Match preview
Lens manager Franck Haise and his troops may have taught Arsenal a defensive lesson during their 2-1 win over the Gunners in October, but Les Sang et Or's previous rearguard excellence eluded them during last month's trip to North London, which ended in a 6-0 obliteration.
Six goals from six different scorers sent Arsenal through to the last 16 as group winners, and with PSV Eindhoven also completing an astonishing comeback over Sevilla on the penultimate matchday, Lens' first Champions League adventure in 21 years will be ending at the first hurdle.
However, the third-placed Sang et Or have their Europa League fate in their own hands and will drop into the knockout round playoffs of Europe's secondary tournament if they can take at least a point off their visitors on Tuesday, but defeat would eliminate them from Europe entirely given their inferior goal difference.
A point was all that Haise's men managed to clean from their most recent Ligue 1 encounter away to Montpellier HSC on Friday, failing to convert their 65% possession into anything meaningful, although that bore draw did extend Lens' unbeaten streak in the French top flight to 10 matches.
Furthermore, home has been where the heart is for Lens in recent weeks, as they have defeated Nantes, Marseille and Lyon in each of their last three matches at the Stade Bollaert-Delelis and have only ever lost one Champions League home game - a 3-1 beating at the hands of Dynamo Kiev in 1998.
An hour of perfection preceded 30 minutes of implosion for Sevilla against PSV Eindhoven on matchday five, as goals from Sergio Ramos and Youssef En-Nesyri seemingly set Diego Alonso's side on the way to their first Champions League win of the new term, which would have blown the fight for second place wide open.
However, after Lucas Ocampos was given his marching orders for two bookable offences inside three minutes, Sevilla capitulated at the Ramon Sanchez Pizjuan, where an Ismael Saibari effort and Nemanja Gudelj own goal preceded an injury-time Ricardo Pepi header in an astounding 3-2 win for the Dutch giants.
Veteran midfielder Fernando was also given a red card as Sevilla's last-16 hopes crashed and burned, leaving Los Palanganas' Group B adversaries looking down on them in fourth place, but a first victory at the sixth attempt would see Alonso's men sneak into their favoured Europa League.
Such a scenario is fanciful if recent form is anything to go by, though, as a 1-0 loss to Mallorca at the weekend extended the visitors' winless run in La Liga to an alarming nine matches, and their only two wins since October have been Copa del Rey successes against lower-league opponents in Quintanar and Atletico Astorga.
Speaking of unwanted nine-match runs, Sevilla have gone an identical period of time without a Champions League away win, but they held Lens to a 1-1 draw in their maiden Group B contest and are yet to lose a top-level European match away to a Ligue 1 opponent.
Lens Champions League form:
D
W
D
L
L
Lens form (all competitions):
L
W
W
L
W
D
Sevilla Champions League form:
D
D
L
L
L
Sevilla form (all competitions):
D
L
L
D
W
L
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Team News
Owing to his sending-off on matchday four against PSV Eindhoven, Lens attacker Morgan Guilavogui sat out the crushing defeat to Arsenal at the Emirates, but the 25-year-old Guinea international is now eligible for European selection once again.
That is more than can be said for ACL victims Jimmy Cabot and Wuilker Farinez, although the latter is at least back in training once again, while Deiver Machado (groin) and Ayanda Sishuba (thigh) are also expected to spend at least another couple of weeks on the sidelines.
A few selection surprises were sprung by Haise against Montpellier, but trusted performers such as Nampalys Mendy, Angelo Fulgini and Florian Sotoca - back from a domestic ban - should be trusted from the first whistle for Tuesday's encounter.
As Sevilla players lost their rag against PSV, Alonso has now lost two of his regular starters to suspension, as winger Ocampos and lynchpin Fernando will watch this one from the naughty step alongside coach Juanito, the third member of the Sevilla contingent to see red in that game.
However, Fernando is nursing a shoulder concern anyway and is one of a host of injury worries for Alonso, who is also without Alfonso Pastor (knee), Suso (thigh), Orjan Nyland (thigh), Mariano Diaz (discomfort), Tanguy Nianzou (hamstring), Jesus Navas (hamstring), Erik Lamela (calf), Loic Bade (calf) and Marcos Acuna (hamstring).
Sevilla's fitness crisis worsened when Dodi Lukebakio was taken off in the first half of their loss to Mallorca with a knee injury, which is expected to render him unavailable for Tuesday's game, and with Adnan Januzaj not registered for Champions League action, Rafa Mir should fill the void.
Lens possible starting lineup:
Samba; Medina, Danso, Gradit; Frankowski, Abdul Samed, Mendy, Haidara; Sotoca, Fulgini; Wahi
Sevilla possible starting lineup:
Dmitrovic; Sanchez, Ramos, Gudelj, Pedrosa; Rakitic, Soumare, Sow; Torres, En-Nesyri, Mir
We say: Lens 1-0 Sevilla
Bereft of reinforcements in all areas of the field and struggling for inspiration domestically, Sevilla ought to travel to France in hope more than expectation, especially with Lens always a force to be reckoned with in front of their expectant crowd.