The sides head into this one off the back of contrasting results last time out, but the game promises to be an exciting one nonetheless.
Match preview
Lanus still await their first win of the new campaign after they were beaten 2-1 by Atletico Tucuman at the Estadio Monumental Jose Fierro on Wednesday.
Jorge Almiron's men opened the scoring 11 minutes shy of the interval through Lucas Varaldo before a second-half brace from Ramiro Carrera turned the game on its head.
With two points from three matches so far, El Granate currently sit bottom but three in the league table and will need to get their season up and running as soon as possible.
Next up is a clash versus an opposing side who they have beaten in four of the most recent five encounters between the teams dating back to 2018.
Ahead of a daunting assignment against River Plate one week later, Sunday's hosts will be looking to record a morale-boosting victory this weekend.
Colon picked up their first three points of the new season following a 1-0 victory against River Plate on Wednesday at the Estadio Brigadier General Estanislao Lopez.
Julio Cesar Falcioni's men broke the deadlock in the 74th minute courtesy of Ramon Abila's opener, and that was enough to get the job done in Santa Fe.
As a result, the Tarpon Fishers have moved up into eighth place in the standings and are now just two points shy of Estudiantes at the top of the pile.
However, Sunday's visitors continue to struggle away from home as they have failed to win any of their last nine games on the road since February 23.
Lanus Argentine Primera Division form:
Lanus form (all competitions):
Colon Argentine Primera Division form:
Colon form (all competitions):
Team News
Mateo Sanabria is a guaranteed absentee for Lanus as he is currently on international duty with the Argentina Under-19s.
Pedro de la Vega and Alexandro Bernabei are both sidelined through injury and are also unavailable for the home side.
Forty-one-year-old Jose Sand could make his return to action this weekend having missed the last two games with a hamstring problem.
Despite failing to extend his goalscoring streak to four games last time out, Colon's Facundo Farias remains one to keep an eye on.
Paolo Goltz and Cristian Vega will not play any part for the away side in this one as they continue to nurse muscle and knee injuries respectively.
Lanus possible starting lineup:
Monetti; Pasquini, Cabral, Perez, Di Placido; Malcorra, Belmonte, Aguirre; Acosta, Varaldo, Gonzalez
Colon possible starting lineup:
Burian; Meza, Acevedo, Novillo, Teuten; Lertora, Aliendro, Bernardi; Farias, Pierotti, Abila