Dortmund returned to winning ways against Borussia Monchengladbach last weekend, but they head into this encounter 10 points behind their forthcoming opponents.
Match preview
Leverkusen, of course, have been winning all season. Xabi Alonso's side's comfortable 3-0 victory away to Werder Bremen was their 11th win in 12 league games this season, meaning only second-placed Bayern Munich have prevented them from winning in all competitions.
Jeremie Frimpong and Alex Grimaldo continued their sensational goalscoring form from the wing-back areas after Olivier Deman's early own goal had handed their side an early lead at Weserstadion. Leverkusen were completely dominant across the course of the match, restricting Werder Bremen to only two shots in total in their own stadium.
Die Werkself proceeded to secure their 18th win in 19 matches by dispatching Hacken 2-0 in Norway in the Europa League on Thursday, with strikers Victor Boniface and Patrik Schick both getting themselves on the scoresheet either side of half-time. As winners of Group H, Leverkusen will bypass the last-32 stage of Europe's secondary competition and head straight into the round-of-16 from March 2024 onwards.
As such, Alonso and his players have three months to focus on the domestic competitions, as they look to win the club's first trophy for over three decades. They have a winnable home tie against Paderborn in the third round of the DFB-Pokal on Tuesday, which is sandwiched by massive matches against fourth-placed Dortmund and third-placed Stuttgart in the Bundesliga.
With the reigning champions Bayern continuing to rack up wins only two points behind them, Leverkusen could find themselves kicking-off against BVB in second position should the Bavarians dispatch Union Berlin earlier in the weekend as expected. It is clearly a pivotal week in the club's campaign as they look to build on their exceptional opening period in their quest for glory in at least one competition.
Having come so close to finally dethroning Bayern as champions last season, when they failed to beat Mainz 05 at Westfalenstadion as was required to lift the title on the final day of the campaign, Dortmund surely require all three points at Bay-Arena if they are to stand any chance of winning the Bundesliga for the first time since 2012.
BVB came from two goals behind to defeat Gladbach last time out in the Bundesliga, with Marcel Sabitzer, Niclas Fullkrug and Jamie Bynoe-Gittens overturning their side's early deficit during a crazy first half. The victory saw them leapfrog Leipzig into fourth place in the table.
In reality, in terms of the title picture, an eight-point deficit to Bayern after 12 matches may prove impossible to recover regardless of whether Leverkusen can continue their phenomenal form, meaning Edin Terzic's focus may be on the cup competitions and ensuring his side's qualification for the Champions League next season.
BVB have performed exceptionally in Europe's elite competition this time out, with their 3-1 win away to AC Milan booking their place in the knockout stages with a game to spare. Despite being drawn alongside Paris Saint-Germain, Newcastle United and Milan in the 'Group of Death', Terzic's side will progress as group winners if they can avoid defeat to PSG on the final matchday later this month.
Dortmund have a difficult trip to high-flying Stuttgart in the third round of the DFB-Pokal on Tuesday, before hosting potential Champions League qualification rivals RB Leipzig next weekend. However, they must be fully focused and performing close to their best levels if they are to stand any chance of inflicting Leverkusen's first defeat of the season, and realistically remain in the title race in the process.
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Borussia Dortmund Bundesliga form:
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Team News
Leverkusen will remain without Arthur due to a long-term thigh injury, but Florian Wirtz is in contention to start despite being withdrawn against Werder Bremen due to a muscle injury. The 20-year-old has been in exceptional form this season, so Alonso will be giving the Germany international every chance of starting.
Alonso made eight changes for his side's trip to Gothenburg on Thursday, with only Boniface, Robert Andrich and Piero Hincapie retaining their starting berths from their team's win in Bremen. The Spaniard will pick what he considers to be his strongest XI for such a big match, meaning Jonas Hofmann and Granit Xhaka will almost certainly start.
Dortmund, meanwhile, will travel without Julian Duranville and Felix Nmecha due to thigh and hip issues, while Marcel Lotka is suspended. Niklas Sule is a major doubt due to illness after missing the trip to San Siro in midweek.
Terzic's only change between his side's wins against Gladbach and Milan was bringing Donyell Malen in for Julian Brandt in midweek, and he is likely to bring the Germany attacking midfielder back into the fold here due to his technical proficiency.
Bayer Leverkusen possible starting lineup:
Hradecky; Kossounou, Tah, Tapsoba; Frimpong, Palacios, Xhaka, Grimaldo; Hofmann, Wirtz; Boniface
Borussia Dortmund possible starting lineup:
Kobel; Ryerson, Hummels, Schlotterbeck, Bensebaini; Can, Sabitzer; Reus, Brandt, Bynoe-Gittens; Fullkrug
We say: Bayer Leverkusen 3-2 Borussia Dortmund
There is little doubt that this match is the stand-out game of the weekend in the Bundesliga, with both teams desperate for all three points for different reasons. Leverkusen will need to win to return to the top of the table should Bayern defeat Union Berlin as expected, while Dortmund must close the gap on their opponents.
Despite Dortmund's hugely positive week, Leverkusen are playing at a higher level at the moment, and we can envisage them coming out on top in what could be a classic encounter.