Pep Guardiola's side smashed Leeds in midweek to stay top of the table.
City have been in superb form recently and will be brimming with confidence ahead of their trip to St. James'.
Newcastle have still only won once all season and lost at Liverpool on Thursday night.
Eddie Howe and co must start picking up points but that'll be a tough task against City.
Newcastle v Man City: Date and time
This Premier League clash will take place on Sunday, December 19.
The clash will be held at St. James' Park with a kick-off time of 2pm.
City beat Newcastle home and away last season including a thrilling 4-3 win in this fixture.
Newcastle v Man City: How to follow
This match will also be broadcast live on Sky Sports Main Event and Sky Sports Premier League with live coverage starting from 1pm.
Sky Sports customers can live stream this via the app using their mobile, tablet or computer devices.
If not, you can purchase a Sky Sports Day Pass from NowTV for £9.99.
Newcastle v Man City: Team news
Allan Saint-Maximin is a doubt for this clash with a minor issue.
Federico Fernandez is out again while Jamal Lewis has a hamstring injury and could miss out.
Paul Dummett is not fit to return yet.
Kyle Walker and Bernardo Silva could miss out for its with slight fitness problems.
Ferran Torres remains their only major absentee.
Newcastle v Man City: What has been said?
Guardiola could miss the game after returning an inconclusive coronavirus test result.
The City boss cancelled his scheduled press conference on Friday lunchtime while he awaits the result of a follow-up PCR test.
Should it prove positive and the Spaniard be asked to isolate, he would not only miss the trip to St James' Park but also the home clash with Leicester on Boxing Day.
At present, Sunday's game is one of only five in the top flight still due to go ahead this weekend following a raft of postponements amid the latest rise in Covid rates.
Guardiola, who lost his mother to the virus last year, was last seen in public on Wednesday when he represented City at Sergio Aguero's retirement announcement in Barcelona.
The 50-year-old was wearing a mask for the main presentation and has been quite vocal on the need for, not only his players, but society in general to maintain high levels of caution.
"I'm concerned - not because we are going to cancel or break the league but because in society the virus is here and people suffer," he said earlier this week.
"Some people, staff here, have got it right now and we've spoken with the players almost every day and told them to be careful - stay safe, stay healthy, (wear) masks, social distance."
Newcastle v Man City: Match facts
Newcastle have won just one of their last 27 Premier League games against Manchester City (D4 L22), winning 2-1 at St James' Park in January 2019.
Manchester City have lost just one of their last 13 away league games against Newcastle (W9 D3). However, they've conceded seven goals across their last three visits to St James' Park, more than they had in their previous 11 combined (6).
Manchester City have scored in each of their last 25 Premier League games against Newcastle, last failing to do so in a 0-0 draw in November 2006. In the competition's history, only Arsenal have had a longer scoring streak against a specific opponent (26 vs West Brom).
Newcastle are unbeaten in their last five home league games against reigning top-flight champions, winning two and drawing three. They last had a longer such run between October 1987 and October 1996, a six-game run of which the final game was a 5-0 victory against Manchester United.
Newcastle picked up their first Premier League win of the season in their last home game, beating Burnley 1-0. They've not won back-to-back Premier League home games since December 2019.
Manchester City have won 33 Premier League games in 2021 - one more victory will see them set a new top-flight record for most wins in a single calendar year.
Manchester City have won each of their last seven Premier League games, scoring 20 goals and conceding just three. It's more wins than the Citizens had picked up in their first 10 league games this term (W6 D2 L2).
Against no side have Manchester City netted more Premier League hat-tricks than they have against Newcastle (3), with Ferran Torres scoring a treble in this exact fixture last season.
Newcastle boss Eddie Howe has lost all 10 of his Premier League games against Manchester City - the worst 100% losing record any manager has against a specific opponent in the competition's history.
Riyad Mahrez has scored 49 goals in 164 games for Manchester City in all competitions, with only Sergio Agüero (61), Gabriel Jesus (63) and Raheem Sterling (76) netting more for the Citizens since he joined the club in 2018.