The French hosts have already sealed top spot in Group A, while the visitors have also secured their place in the quarter-finals.
Match preview
Lyon have made a positive start to their bid to add to their record haul of eight European trophies, having taken maximum points from each of their six group matches.
The French side won their opening three group games by a combined 8-0 scoreline, before they eased to a 4-1 home victory against Roma on matchday four.
Joe Montemurro's side produced another free-scoring display in last week's clash against Galatasaray, with Ada Hegerberg, Sara Dabritz, Wendie Renard, Danielle van de Donk and Eugenie Le Sommer all finding the net in a 6-0 victory.
After enjoying a successful trip to Turkey, Lyon marked their return to domestic action with a 5-1 win against Nantes, maintaining their three-point lead over Paris Saint-Germain at the top of the Premiere Ligue.
They will turn their focus to their final outing of 2024, and while they have already wrapped up top spot in Group A, they will still be keen to claim a 10 straight competitive victory and maintain their unbeaten record in all competitions.
Wolfsburg will join Lyon in the UWCL quarter-finals after they secured a top-two spot with a commanding win over Roma last week.
They went into matchday five with nine points to their name after they bounced back from defeats against Roma and Lyon to record back-to-back European wins over Galatasaray.
The German side then produced an impressive performance to sweep past Roma via a 6-1 scoreline, thanks to four goals from Sveindis Jonsdottir as well as efforts from Alex Popp and Lineth Beerensteyn.
That result moved them three points clear of the Italian champions, while also giving them the all-important head-to-head advantage, ensuring they will maintain their 100% record of progressing from the UWCL group stage.
Wolfsburg will head to France off the back of a 3-1 away win over Werder Bremen in the Frauen-Bundesliga, representing their fifth victory in their last six competitive away games.
Lyon Women Women's Champions League form:
W
W
W
W
W
Lyon Women form (all competitions):
L
W
W
W
W
W
Wolfsburg Women Women's Champions League form:
W
L
L
W
W
W
Team News
Lyon goalkeeper Christiane Endler is set to return to the starting XI after being rested for Saturday's league game.
Alice Sombath and Selma Bacha could come back into the side to feature in a back four alongside Ellie Carpenter and Wendie Renard.
Van de Donk and Dabritz are likely to return to the midfield, while UWCL's all-time record goalscorer Hegering is expected to be recalled to the lineup.
As for the visitors, they will be without long-term absentees Kristin Deman and Camilla Kuver, while Luca Papp is unlikely to be available for Tuesday's away fixture.
Wolfsburg head coach Tommy Stroot has already confirmed that Lisa Schmitz will miss the game with a minor shoulder problem.
Beerensteyn will be looking to continue her impressive form in front of goal, having scored 11 times in 18 competitive appearances this season.
Lyon Women possible starting lineup:
Endler; Carpenter, Sombath, Renard, Bacha; Van de Donk, Egurrola, Dabritz; Diani, Dumornay, Hegeberg
Wolfsburg Women possible starting lineup:
Frohms; Wilms, Minge, Hegering, Linder; Beerensteyn, Huth, Lattwein, Brand; Blomqvist, Popp
We say: Lyon Women 3-1 Wolfsburg Women
While both sides have already clinched qualification, they will be keen to finish the calendar year on a high and build confidence ahead of the knockout rounds.
Written by
Ben Sully