Fraser Forster and Yves Bissouma both contracted the virus ahead of the 6-3 win over Team K-League, and the pair will miss out here as they continue to self-isolate.
On a brighter note, Ivan Perisic and Dejan Kulusevski are pushing to be involved as they step up their recoveries from calf issues, while Ben Davies could earn some minutes too.
Brandon Austin was given the nod for the first half of the win over Team K-League, but Hugo Lloris could start this one given the calibre of opposition.
Eric Dier, Cristian Romero and Davinson Sanchez are unlikely to be afforded any breaks just yet, but Japhet Tanganga should get some game time as he builds up his match fitness again.
Pierre-Emile Hojbjerg and Rodrigo Bentancur could form the midfield pairing in the absence of Bissouma, as the impressive Harvey White warms the bench alongside Pape Sarr and Oliver Skipp.
A change in the full-back areas could see Emerson Royal make way for Matt Doherty, as Ryan Sessegnon holds his place on the left with Sergio Reguilon not making the journey.
Harry Kane and Son Heung-min both hit braces off the bench in Wednesday's nine-goal win, and a second consecutive start could also come Richarlison's way.
Tottenham possible starting lineup: Lloris; Romero, Dier, Sanchez; Doherty, Hojbjerg, Bentancur, Sessegnon; Richarlison, Kane, Son
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