The 32-year-old sat out the 1-0 win over AZ Alkmaar in the Europa League due to being "a bit sore" after the 4-1 top-flight thrashing of West Ham United, although Postecoglou revealed that it was always the plan to rest him in midweek.
Son is not believed to be nursing anything serious, and the same goes for Djed Spence (groin), but the latter was only training individually earlier this week and will likely be kept in reserve for the time being.
Timo Werner endured another wasteful evening in front of goal on Thursday and is primed to drop out for the returning Son, while Dominic Solanke and Brennan Johnson are also set to come back in for Richarlison and the effervescent Mikey Moore.
However, one or two players who should hold their spot is stand-in skipper James Maddison, who captained Tottenham to their victory over AZ and is now set to make his 200th appearance in the Premier League.
The Englishman ought to link arms with Yves Bissouma and Dejan Kulusevski in an unchanged midfield from the win over West Ham, while Destiny Udogie is the only other player who should reprise their role from the Europa League.
Fraser Forster impressed in between the sticks on Thursday, but Guglielmo Vicario will now reclaim the gloves, while Micky van de Ven, Cristian Romero and Pedro Porro are also primed to return to the rearguard.
Tottenham Hotspur possible starting lineup:
Vicario; Porro, Romero, Van de Ven, Udogie; Kulusevski, Bissouma, Maddison; Johnson, Solanke, Son