The Reds have the chance to open up a seven-point lead over the Gunners in the top-flight table, but they will have to manage without Alisson Becker (hamstring), Harvey Elliott (foot) and Federico Chiesa (fitness) once again.
Diogo Jota is also expected to sit this one out due to the whack to his side that he suffered in last weekend's 2-1 win over Chelsea, and Conor Bradley's status is also unclear after he missed Liverpool's last two matches.
With Jota on the treatment table, Darwin Nunez spearheads the charge on the back of scoring the Reds' only goal in their 1-0 Champions League victory over RB Leipzig on Wednesday, a result that made it six wins from six away games under Slot.
Mohamed Salah and Dominik Szoboszlai will form part of Nunez's supporting cast, but Slot is facing the best kind of dilemma on the left, where Luis Diaz may now displace Cody Gakpo.
Curtis Jones may have propelled Liverpool to victory against Chelsea, but Alexis Mac Allister and Ryan Gravenberch are Slot's undisputed first-choice pairing and are primed to link arms in the centre once more.
The visiting manager should make just one change to the rearguard from the win in Leipzig, as Andy Robertson comes back in for Kostas Tsimikas, while Caoimhin Kelleher continues to deputise in goal for Alisson after making a string of crucial saves in midweek.
Liverpool possible starting lineup:
Kelleher; Alexander-Arnold, Konate, Van Dijk, Robertson; Mac Allister, Gravenberch; Salah, Szoboszlai, Diaz; Nunez