Ange Postecoglou's side stayed perfect in the Europa League thanks to a 1-0 win over AZ Alkmaar on Thursday night, where Richarlison's penalty was the only difference between the two sides.
That slender success came after a far more emphatic 4-1 beating of West Ham United in last weekend's capital derby, a result that lifted Spurs firmly into European contention in seventh place in the table.
Here, Sports Mole rounds up all of Spurs' latest injury and suspension news ahead of the clash with the Eagles, whose misfortunes continued in a 1-0 loss to Nottingham Forest on Monday.
Son Heung-min
Status: Minor doubt
Type of injury: Knock
Possible return date: October 27 (vs. Crystal Palace)
Son Heung-min was "a bit sore" following the victory over West Ham and was rested for the midweek clash with AZ, but there is a good chance that the South Korean will be back in contention here.
Djed Spence
Status: Major doubt
Type of injury: Groin
Possible return date: October 27 (vs. Crystal Palace)
Djed Spence was Spurs' only other absentee for the success over AZ due to his groin issue, and the right-back is only believed to be in with a slim chance of making the squad at Selhurst Park.
TOTTENHAM'S SUSPENSION LIST
Tottenham have no players suspended for Sunday's derby.