Coman was substituted early in the second half of Bayern's 2-0 win against FC Koln after experiencing discomfort. The Frenchman was seen clutching his right groin as he exited the pitch.
Jamal Musiala came on to replace him in the 49th minute, and Coman had to be assisted off the field by two members of Bayern's medical staff.
Coman adds to Bayern Munich's injury woes
The Bavarians are already dealing with the absence of winger Serge Gnabry, who sustained a hamstring injury upon his return to the Emirates Stadium.
In addition, Tarek Buchmann and Bouna Sarr are likely to miss the remainder of the season due to injury, while Leroy Sane and Sacha Boey are questionable.
Bayern will also be without left-back Alphonso Davies against Mikel Arteta's Gunners due to suspension after he received a yellow card in north London last week.
If Coman is unable to play against Arsenal, it is probable that Musiala will feature on the wing, with Harry Kane leading the attack.
The potential absence of the French international will provide Arsenal with a welcomed boost. In the first leg, the Gunners controlled the game and would likely have felt they deserved to win the match.
However, two defensive mistakes in the first half allowed Bayern Munich to stay in the match, leaving the tie hanging in the balance ahead of the second leg.
The Bavarians are on the verge of relinquishing the Bundesliga crown for the first time since Jurgen Klopp's Borussia Dortmund edged them to the title in the 2011-12 season.
Bayer Leverkusen will have the opportunity to secure their first-ever league title when they face Werder Bremen at what should be a packed house at BayArena on Sunday.