Hansi Flick's side came from behind to record a 2-1 victory over Valencia in their season opener, before beating Athletic Bilbao 2-1 in their second game of the campaign.
Barcelona were also 2-1 winners in their third game of the season on Tuesday night, coming from behind to beat Rayo Vallecano, with Dani Olmo hitting the winner on his debut for the club.
Here, Sports Mole rounds up Barcelona's injury and suspension news ahead of Saturday's contest with Real Valladolid, who were beaten 3-0 by Real Madrid in their last away match.
Ansu Fati
Status: Out
Type of injury: Foot
Possible return date: Unknown
Barcelona remain without Fati, who picked up a foot injury at the end of July; the forward has been linked with a late summer exit, but head coach Flick has said that he wants to keep hold of him.
Ronald Araujo
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Araujo will be on the sidelines until the latter stages of this year due to the hamstring operation that he underwent in the middle of July.
Frenkie de Jong
Status: Out
Type of injury: Ankle
Possible return date: Unknown
De Jong has been absent since the start of March due to an ankle problem, and it is unclear when the Netherlands international will be able to make his Barcelona return.
Gavi
Status: Out
Type of injury: Knee
Possible return date: Unknown
Gavi continues to recover from the serious knee injury that he suffered while representing Spain towards the end of last year, but he is expected to be back on the field before the end of 2024.
Andreas Christensen
Status: Out
Type of injury: Achilles
Possible return date: Unknown
Christensen is on the treatment table with an Achilles problem, and it is understood that the Denmark international could be on the sidelines for the next couple of months.
Eric Garcia
Status: Out
Type of injury: Foot
Possible return date: Unknown
Garcia, who returned to Barcelona over the summer after a loan spell at Girona, was sidelined against Rayo Vallecano due to a foot issue, and he is again set to miss out this weekend.
Marc Bernal
Status: Out
Type of injury: Knee
Possible return date: Unknown
Barcelona are fearful that 17-year-old Bernal suffered an ACL injury in the latter stages of Tuesday's clash against Rayo Vallecano, with the club currently assessing the seriousness of the damage.
BARCELONA'S SUSPENSION LIST
Barcelona have no players suspended for the league clash.
Khimki 
Lokomotiv Moscow 
Crvena Zvezda 
Benfica 
Feyenoord 
Bayer Leverkusen 
Spartak Moscow 
Krylya Sovetov 
Atalanta 
Arsenal 
Atletico Madrid 
RB Leipzig 
Monaco 
Barcelona 
Bordeaux 
Quevilly 
Pec Zwolle 
AZ Alkmaar 
Alaves 
Sevilla 
West Ham 
Chelsea 
Sampdoria 
Sudtirol 
Werder Bremen 
Bayern Munich 
Leicester 
Everton 
Liverpool 
Bournemouth 
Tottenham 
Brentford 
Dynamo Kyiv 
Rukh Lviv 
Juventus 
Napoli 
Rubin 
CSKA Moscow 
Voltigeurs De Chateaubriant 
Crystal Palace 
Manchester Utd 
Eintracht Frankfurt 
Borussia Monchengladbach 
Rangers 
Dundee 
Valencia 
Girona 
Vitoria Guimaraes 
FC Porto 
Rodez 
Go Ahead Eagles 
Ajax 
Reims 
Paris Saint Germain 
Real Madrid 
Espanyol 
Fiorentina 
Lazio