The winners of this two-legged tie will qualify for the newly-expanded 36-team Europa League, while the losers will drop down into the Conference League.
Match preview
Shamrock's hopes of qualifying for the Europa League proper for just the second time in their history are hanging by the finest of threads, after there were heavily beaten 4-0 by PAOK away from home in last week's first leg.
It looked as if the Hoops would enter half time level until Daniel Cleary's own goal handed PAOK the lead in the fourth minute of first-half stoppage time, before Taison added a second for the Greek visitors just two minutes after the interval.
Josh Honohan was then sent off for Shamrock on the 52-minute mark for a second bookable offense, and PAOK took advantage by netting their third and fourth goals through Giannis Konstantelias and Baba Rahman to all but secure their place in the Europa League.
Stephen Bradley has admitted that "winning the tie is near impossible" for his Shamrock side, but he still has aspirations of at least coming out on top in the second leg and want his players to "reproduce" their first-half performance from Greece in order to achieve that on home soil.
Shamrock have since played out a 1-1 draw with Galway United in the League of Ireland Premier, meaning they have won just three of their last 11 matches in all competitions and have slipped 10 points behind league leaders Derry City, who have played two games more.
PAOK, meanwhile, have kick-started the defence of their Greek Super League title in positive fashion, as they have won their opening two matches of the new season, following up a 3-2 win over Panserraikos with a 2-0 victory against Panaitolikos last weekend.
Second-half strikes from Joan Sastre and Tarik Tissoudali helped the Aspromavri claim their third successive win within the space of eight days, much to the delight of head coach Razvan Lucescu, whose team were left disappointed by their elimination in the Champions League qualifiers earlier this month.
PAOK's recent success has all taken place on home soil and they are now gearing up for just their second competitive away match of the season and their first since playing out a 2-2 Champions League draw with Malmo on August 6; PAOK have lost just five of their 18 away games since the beginning of this year.
The Aspromavri, who reached the Conference League quarter-finals last season, now have their eyes set on securing their place in the Europa League for the first time since competing in the 2020-21 group stage.
Shamrock Rovers Europa League form:
L
W
L
Shamrock Rovers form (all competitions):
W
L
D
W
L
D
PAOK Europa League form:
W
PAOK form (all competitions):
W
D
L
W
W
W
Team News
Shamrock Rovers will be without the suspended Honohan after his red card in the first leg, while Johnny Kenny and Rory Gaffney remain sidelined with injuries.
The absence of Honohan could see Darragh Burns handed a start at right wing-back, with Trevor Clarke operating on the opposite flank.
Daniel Mandroiu scored his first goal since re-joining Shamrock in last weekend's draw with Galway, and he will be pushing to start in attack along with Aaron Greene.
As for PAOK, their only injury concern is with forward Brandon, who is ruled out with an ankle injury and has not travelled to Ireland.
Fyodor Chalov is therefore in contention to start up front and could be supported in attack by Andrija Zivkovic, Giannis Konstantelias and Taison.
Jonny Castro and Baba Rahman, two former Premier League full-backs, are set to be recalled at the expense of Joan Sastre and Rafa Soares, while Stefan Schwab could be joined in centre-midfield by Magomed Ozdoyev.
Shamrock Rovers possible starting lineup:
Pohls; Hoare, Cleary, Grace; Burns, Watts, O'Neill, Clarke; Nugent, Mandroiu; Greene
PAOK possible starting lineup:
Kotarski; Jonny, Kedziora, Michailidis, Baba; Ozdoev, Schwab; Zivkovic, Konstantelias, Taison; Chalov
We say: Shamrock Rovers 1-2 PAOK (PAOK to win 6-1 on aggregate)
Shamrock are merely playing for pride as they are aware that they require a miracle to progress to the Europa League. Bradely is keen for his team to put in a positive display in front of their own fans, though, before they all but certainly drop down into the Conference League.
PAOK, meanwhile, are in high spirits and will be keen to build on their positive start to the campaign, so we can see them coming out on top in the second leg and securing a comfortable aggregate victory.