Achraf Hakimi was suspended for the first leg but is available for this match, and he is set to return to the side, with Nuno Mendes potentially dropping down to the bench.
Vitinha is a certain starter in central midfield, while Fabian Ruiz should also keep his spot, but Warren Zaire-Emery could be introduced in that area of the field.
Marco Asensio found it difficult to make his mark in the first leg, and there could now be a start at centre-forward for Goncalo Ramos, with Ousmane Dembele and Kylian Mbappe featuring in the wide positions.
Mbappe has four career goals to his name against Barcelona and will be looking to make his mark following a disappointing performance in the first leg last week.
Presnel Kimpembe, Layvin Kurzawa and Sergio Rico remain on the sidelines, while Nordi Mukiele will need to be assessed due to a head injury, but there are no fresh fitness issues for the capital giants.
Enrique decided against using Randal Kolo Muani in the first leg, but the France international is another attacking option, while Bradley Barcola will also be in the manager's thoughts when it comes to possible changes, as PSG look to bounce back from a 3-2 loss on home soil.
Paris Saint-Germain possible starting lineup: Donnarumma; Hakimi, Marquinhos, Beraldo, Hernandez; Zaire-Emery, Ruiz, Vitinha; Dembele, Ramos, Mbappe