Mikel Arteta's men did not blow Wolverhampton Wanderers to smithereens on the opening weekend, but a Kai Havertz header and Bukayo Saka finish were enough for a routine 2-0 victory.
The Gunners now reunite with erstwhile manager Unai Emery, whose side dealt two crushing blows to their title aspirations last season, where they were the only team to do the double over the capital club.
Here, Sports Mole rounds up all of Arsenal's latest injury and suspension news ahead of their clash with Villa, who edged out West Ham United 2-1 in gameweek one.
Takehiro Tomiyasu
Status: Out
Type of injury: Knee
Possible return date: September 15 (vs. Tottenham Hotspur)
Still unable to shake the injury curse, Takehiro Tomiyasu is on the mend from a severe knee problem which ruined his pre-season preparations, and the Japan international is not expected back until the middle of September.
Kieran Tierney
Status: Out
Type of injury: Hamstring
Possible return date: September 15 (vs. Tottenham Hotspur)
Tomiyasu's fellow full-back Kieran Tierney is facing a similar period of recuperation from the hamstring issue he picked up at Euro 2024, but there is a good chance that he will leave before the end of the month anyway.
Fabio Vieira
Status: Minor doubt
Type of injury: Hip
Possible return date: August 24 (vs. Villa)
Portuguese attacker Fabio Vieira sat out the triumph over Wolves with a hip problem, but he was close to making the cut last weekend and ought to be fine for Saturday.
ARSENAL'S SUSPENSION LIST
Arsenal have no players suspended for this fixture.