Wednesday's Copa Sudamericana predictions including Fortaleza vs. Rosario Central

Fortaleza vs. Rosario (Wednesday, 11.00pm)

Seeking a place in the quarter-finals of the Copa Sudamericana for a second successive campaign, Fortaleza host Rosario Central in the second leg of their last-16 tie on Wednesday at Arena Castelao.

A goal from each side within the opening six minutes last week means that this tie is all square at 1-1 heading into this decisive encounter.

We say: Fortaleza 1-0 Rosario Central (Fortaleza advance 2-1 on aggregate)

The Brazilians have a lot of momentum at home heading into this contest, and their recent experience in these must-win games should propel them to a narrow triumph.

Medellin vs. Palestino (Thursday, 1.30am)

Independiente Medellin and Palestino return to action in the Copa Sudamericana when they go head to head in the second leg of their round-of-16 clash on Wednesday.

With last week's reverse leg ending in a pulsating stalemate, a place in the quarter-finals is very much up for grabs and we expect both sides to go all out at the Estadio Hernan Ramirez Villegas.

We say: Independiente Medellin 2-1 Palestino

Following last week's result, Independiente Medellin and Palestino will need no extra motivation on Wednesday as they look to reach the Copa Sudamericana quarter-finals - a stage they have both never progressed past in the history of the tournament.

While we expect both sides to go all out at the Estadio Hernan Ramirez Villegas, we fancy the Colombian outfit to come away with a narrow victory in front of their home supporters.

Lanus vs. LDU Quito (Thursday, 1.30am)

Lanus will host LDU Quito at the Estadio Ciudad de Lanus - Nestor Diaz Perez on Thursday for the second leg of their Copa Sudamericana round-of-16 tie.

The hosts hold a 2-1 advantage from the first leg at the Rodrigo Paz Delgado Stadium last week and will be looking to secure their place in the quarter-finals on home soil.

We say: Lanus 2-1 LDU Quito (Lanus advances 4-2 on aggregate)

Lanus picked up an important victory on the road in the first leg, which sets them up well to take advantage of LDU Quito's need to attack, while they will also be boosted by home support, which could prove too much for the visitors to handle.