The Racecourse Ground will host MK Dons on the opening day of the League Two season on August 5 at 3pm.
It is a tough welcome back to the EFL with MK Dons dropping down from League One last season in agonising circumstances - needing just a goal on the final day to secure survivial.
Red Dragons owners Rob McElhenney and Ryan Reynolds have been busy preparing for life in League Two after a magnificent National League title winning campaign.
Wrexham needed 111 points to secure automatic promotion ahead of rivals Notts County, who pushed them all the way.
Their first away trip will be a visit to AFC Wimbledon's Plough Lane on August 12.
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Ben Foster opens up on his Wrexham future & team trip to Vegas
Phil Parkinson's side will be the ones creating the most intrigue in League Two this season, especially with the players they have been linked to.
Goalkeeper Ben Foster has agreed to delay his retirement for another season, by penning a one-year deal.
The latest name they have been linked to is former Manchester United starlet Nick Powell, who has just been released by Championship side Stoke.
Another name that would make a big splash if he does join is Cheltenham striker Alfie May.
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He has scored 43 goals in League One over the last two seasons and has been linked to Charlton.